Ovarian cancer is typically accompanied by the occurrence of malignant ascites containing
large number of macrophages. It has been suggested that these tumor‐associated …

Background Soluble protein and lipid mediators play essential roles in the tumor environment,
but their cellular origins, targets, and clinical relevance are only partially known. We have …

Peroxisome proliferator-activated receptor (PPARs) modulate target gene expression in
response to unsaturated fatty acid ligands, such as arachidonic acid (AA). Here, we report that …

Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is a lipid ligand-inducible transcription
factor with established metabolic functions, whereas its anti-inflammatory function is …

The nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is a lipid
ligand-inducible transcription factor associated with macrophage polarization. However, its …

Macrophages occur as resident cells of fetal origin or as infiltrating blood monocyte-derived
cells. Despite the critical role of tumor-associated macrophages (TAMs) in tumor progression…

DNA-damaging drugs induce a plethora of molecular and cellular alterations in tumor cells,
but their interrelationship is largely obscure. Here, we show that carboplatin treatment of …

Besides its established functions in intermediary metabolism and developmental processes,
the nuclear receptor peroxisome proliferator-activated receptor β/δ (PPARβ/δ) has a less …

The peroxisome proliferator‐activated receptor‐β (PPARβ) has been implicated in tumorigenesis,
but its precise role remains unclear. Here, we show that the growth of syngeneic Pparb …

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors with essential
functions in lipid, glucose and energy homeostasis, cell differentiation, inflammation and …