Tracazolate, a pyrazolopyridine, is an anxiolytic known to interact with γ-aminobutyric acid (GABA)
A receptors, adenosine receptors, and phosphodiesterases. Its anxiolytic effect is …

We have previously identified the 7,8,9,10-tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazine
(1) as a potent partial agonist for the α 3 receptor subtype with 5-fold selectivity in …

We have mutated a conserved leucine in the putative membrane‐spanning domain to
serine in human GABA A β2 and investigated the actions of a number of GABA A agonists, …

Major progress in our understanding of the mechanisms of anaesthesia has been made
during the past year. Several key advances in defining very specific sites of action on ligand-…

The role for Wnt signaling modulation during synaptogenesis, neurogenesis and cell fate
specification have been well characterized. In contrast, the roles for Wnt signaling pathways in …

2, 5-Dihydropyrazolo [4, 3-c] pyridin-3-ones are GABAA receptor benzodiazepine binding
site ligands with functional selectivity for the α3 subtype over the α1 subtype. SAR studies to …

(1) This paper further examines the functional characteristics of recombinant human GABA A
receptors containing the ϵ-subunit expressed in Xenopus oocytes. (2) α1β1ϵ receptors are …

Chemokine receptor antagonists appear to access two distinct binding sites on different
members of this receptor family. One class of CCR 4 antagonists has been suggested to bind to …

Investigation into the modulatory effects of chlormethiazole at human recombinant γ‐aminobutyric
acid A receptor (GABA A ) and N‐methyl‐D‐aspartate (NMDA) receptors was …

Background and Purpose Nasal sensory nerves play an important role in symptoms associated
with rhinitis triggered by environmental stimuli. Here, we propose that TRPV1 is pivotal in …