[HTML][HTML] Rolling circle translation of circular RNA in living human cells

…, Y Nakano, A Shibata, H Maruyama, S Shuto… - Scientific reports, 2015 - nature.com
We recently reported that circular RNA is efficiently translated by a rolling circle amplification
(RCA) mechanism in a cell-free Escherichia coli translation system. Recent studies have …

Highly α- and β-Selective Radical C-Glycosylation Reactions Using a Controlling Anomeric Effect Based on the Conformational Restriction Strategy. A Study on the …

H Abe, S Shuto, A Matsuda - Journal of the American Chemical …, 2001 - ACS Publications
We hypothesized that, because the stereoselectivity of anomeric radical reactions was
significantly influenced by the anomeric effect, which can be controlled by restricting the …

Synthesis and characterization of a series of highly fluorogenic substrates for glutathione transferases, a general strategy

J Zhang, A Shibata, M Ito, S Shuto, Y Ito… - Journal of the …, 2011 - ACS Publications
Glutathione transferases (GSTs) are used in biotechnology applications as fusion partners
for facile purification and are also overexpressed in certain tumors. Consequently, there is a …

Palladium-catalyzed arylation of cyclopropanes via directing group-mediated C (sp3)–H bond activation to construct quaternary carbon centers: synthesis of cis-and …

N Hoshiya, T Kobayashi, M Arisawa, S Shuto - Organic letters, 2013 - ACS Publications
Pd(II)-catalyzed tertiary C(sp 3 )–H arylation of cyclopropanes via directing group-mediated
C–H activation for the construction of a chiral quaternary carbon center on cyclopropanes …

Resolvin E1/E2 ameliorate lipopolysaccharide-induced depression-like behaviors via ChemR23

…, S Ide, M Satoh, K Kaneda, S Shuto… - …, 2018 - Springer
Rationale Resolvins are bioactive lipid mediators that are generated from docosahexaenoic
acid (DHA) and eicosapentaenoic acid (EPA). We recently demonstrated that the DHA-…

1, 2, 3-Triazole-containing uracil derivatives with excellent pharmacokinetics as a novel class of potent human deoxyuridine triphosphatase inhibitors

…, K Itou, K Yamamura, S Shuto… - Journal of medicinal …, 2012 - ACS Publications
Deoxyuridine triphosphatase (dUTPase) has emerged as a potential target for drug
development as a 5-fluorouracil-based combination chemotherapy. We describe the design and …

Sulfur modification of Au via treatment with piranha solution provides low-Pd releasing and recyclable Pd material, SAPd

…, H Yoshikawa, Y Yamashita, S Shuto… - Journal of the …, 2010 - ACS Publications
We have found in the SR-HXPS measurement of Piranha-treated Au(111)/mica that the gold
surface underwent sulfur modification during this treatment, which was believed to have …

Delivering mRNA to Secondary Lymphoid Tissues by Phosphatidylserine‐Loaded Lipid Nanoparticles

…, K Fujiwara, M Watanabe, S Shuto… - Advanced …, 2023 - Wiley Online Library
Lipid nanoparticles (LNPs) are one of the most successful technologies in messenger RNA (mRNA)
delivery. While the liver is the most frequent target for LNP delivery of mRNA, …

From peptides to peptidomimetics: a strategy based on the structural features of cyclopropane

A Mizuno, K Matsui, S Shuto - Chemistry–A European Journal, 2017 - Wiley Online Library
Peptidomimetics, non‐natural mimicries of bioactive peptides, comprise an important class
of drug molecules. The essence of the peptidomimetic design is to mimic the key …

Development of Versatile cis- and trans-Dicarbon-Substituted Chiral Cyclopropane Units:  Synthesis of (1S,2R)- and (1R,2R)-2-Aminomethyl-1-(1H-imidazol-4 …

Y Kazuta, A Matsuda, S Shuto - The Journal of Organic Chemistry, 2002 - ACS Publications
The cyclopropane ring can be used effectively in restricting the conformation of biologically
active compounds to improve activity and also to investigate bioactive conformations. We …