User profiles for Scott R. Walker

Scott R. Walker

Verified email at csiro.au
Cited by 659

[HTML][HTML] New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

…, A Teumer, AAE Vinkhuyzen, RW Walker… - Nature …, 2016 - nature.com
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic
disease risk, we conducted a genome-wide association meta-analysis of body fat …

Variolins and related alkaloids

SR Walker, EJ Carter, BC Huff, JC Morris - Chemical reviews, 2009 - ACS Publications
The phosphorylation of proteins on serine, threonine, and tyrosine residues by the 518 protein
kinases encoded in the human genome constitutes one of the major mechanisms used by …

Intercessory prayer in the treatment of alcohol abuse and dependence: a pilot investigation.

SR Walker, JS Tonigan, WR Miller… - … Therapies in Health …, 1997 - europepmc.org
Objective To conduct a pilot study of the effect of intercessory prayer on patients entering
treatment for alcohol abuse or dependence. Design In addition to standard treatment, 40 …

Genome-wide associations for birth weight and correlations with adult disease

…, NJ Wareham, H Hakonarson, E Davies, BR Walker - Nature, 2016 - nature.com
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in
observational studies is reproducibly associated with future risk of adult metabolic diseases …

[PDF][PDF] Structural determinants for small-molecule activation of skeletal muscle AMPK α2β2γ1 by the glucose importagog SC4

…, R Jacobs, H Huang, MW Parker, JW Scott… - Cell chemical …, 2018 - cell.com
The AMP-activated protein kinase (AMPK) αβγ heterotrimer regulates cellular energy
homeostasis with tissue-specific isoform distribution. Small-molecule activation of skeletal muscle …

[PDF][PDF] Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer

…, R Foitzik, PA Stupple, HR Lagiakos, SR Walker… - Cell Chemical …, 2023 - cell.com
KAT6A, and its paralog KAT6B, are histone lysine acetyltransferases (HAT) that acetylate
histone H3K23 and exert an oncogenic role in several tumor types including breast cancer …

Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling

…, IP Holmes, F Hochgräfe, SR Walker… - Journal of proteome …, 2013 - ACS Publications
Kinase enrichment utilizing broad-spectrum kinase inhibitors enables the identification of
large proportions of the expressed kinome by mass spectrometry. However, the existing …

[PDF][PDF] Whole-genome sequencing coupled to imputation discovers genetic signals for anthropometric traits

…, BR Walker, AS Butterworth, Y Xue, R Durbin… - The American Journal of …, 2017 - cell.com
Deep sequence-based imputation can enhance the discovery power of genome-wide
association studies by assessing previously unexplored variation across the common- and low-…

[HTML][HTML] Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism-and modeling-based design

S Reichau, W Jiao, SR Walker, RD Hutton… - Journal of Biological …, 2011 - ASBMB
Tuberculosis remains a serious global health threat, with the emergence of multidrug-resistant
strains highlighting the urgent need for novel antituberculosis drugs. The enzyme 3-deoxy-…

Concise syntheses of meridianins and meriolins using a catalytic domino amino-palladation reaction

SR Walker, ML Czyz, JC Morris - Organic letters, 2014 - ACS Publications
A synthesis of natural and synthetic members of the meridianin family of kinase inhibitory
natural products has been developed. The sequence utilizes a variation of the Cacchi …