User profiles for Scott R. Walker
Scott R. WalkerVerified email at csiro.au Cited by 659 |
[HTML][HTML] New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
…, A Teumer, AAE Vinkhuyzen, RW Walker… - Nature …, 2016 - nature.com
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic
disease risk, we conducted a genome-wide association meta-analysis of body fat …
disease risk, we conducted a genome-wide association meta-analysis of body fat …
Variolins and related alkaloids
The phosphorylation of proteins on serine, threonine, and tyrosine residues by the 518 protein
kinases encoded in the human genome constitutes one of the major mechanisms used by …
kinases encoded in the human genome constitutes one of the major mechanisms used by …
Intercessory prayer in the treatment of alcohol abuse and dependence: a pilot investigation.
SR Walker, JS Tonigan, WR Miller… - … Therapies in Health …, 1997 - europepmc.org
Objective To conduct a pilot study of the effect of intercessory prayer on patients entering
treatment for alcohol abuse or dependence. Design In addition to standard treatment, 40 …
treatment for alcohol abuse or dependence. Design In addition to standard treatment, 40 …
Genome-wide associations for birth weight and correlations with adult disease
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in
observational studies is reproducibly associated with future risk of adult metabolic diseases …
observational studies is reproducibly associated with future risk of adult metabolic diseases …
[PDF][PDF] Structural determinants for small-molecule activation of skeletal muscle AMPK α2β2γ1 by the glucose importagog SC4
The AMP-activated protein kinase (AMPK) αβγ heterotrimer regulates cellular energy
homeostasis with tissue-specific isoform distribution. Small-molecule activation of skeletal muscle …
homeostasis with tissue-specific isoform distribution. Small-molecule activation of skeletal muscle …
[PDF][PDF] Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer
…, R Foitzik, PA Stupple, HR Lagiakos, SR Walker… - Cell Chemical …, 2023 - cell.com
KAT6A, and its paralog KAT6B, are histone lysine acetyltransferases (HAT) that acetylate
histone H3K23 and exert an oncogenic role in several tumor types including breast cancer …
histone H3K23 and exert an oncogenic role in several tumor types including breast cancer …
Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling
…, IP Holmes, F Hochgräfe, SR Walker… - Journal of proteome …, 2013 - ACS Publications
Kinase enrichment utilizing broad-spectrum kinase inhibitors enables the identification of
large proportions of the expressed kinome by mass spectrometry. However, the existing …
large proportions of the expressed kinome by mass spectrometry. However, the existing …
[PDF][PDF] Whole-genome sequencing coupled to imputation discovers genetic signals for anthropometric traits
Deep sequence-based imputation can enhance the discovery power of genome-wide
association studies by assessing previously unexplored variation across the common- and low-…
association studies by assessing previously unexplored variation across the common- and low-…
[HTML][HTML] Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism-and modeling-based design
Tuberculosis remains a serious global health threat, with the emergence of multidrug-resistant
strains highlighting the urgent need for novel antituberculosis drugs. The enzyme 3-deoxy-…
strains highlighting the urgent need for novel antituberculosis drugs. The enzyme 3-deoxy-…
Concise syntheses of meridianins and meriolins using a catalytic domino amino-palladation reaction
A synthesis of natural and synthetic members of the meridianin family of kinase inhibitory
natural products has been developed. The sequence utilizes a variation of the Cacchi …
natural products has been developed. The sequence utilizes a variation of the Cacchi …