Endosymbiotic associations have played a major role in evolution. However, the molecular
basis for the biochemical interdependence of these associations remains poorly understood. …

The ligands for many olfactory receptors remain largely unknown despite successful
heterologous expression of these receptors. Understanding the molecular receptive range of …

Background Orthologs of the vertebrate ATP gated P2X channels have been identified in
Dictyostelium and green algae, demonstrating that the emergence of ionotropic purinergic …

Kv4.2 subunits, encoded by KCND2, serve as the pore‐forming components of voltage‐gated,
inactivating I SA K + channels expressed in the brain. I SA channels inactivate without …

P2X receptors are membrane ion channels gated by extracellular ATP. Mammals possess
seven distinct P2X subtypes (P2X1-7) that have important functions in a wide array of …

The synovium secretes synovial fluid, but is also richly innervated with nociceptors and acts
as a gateway between avascular joint tissues and the circulatory system. Resident fibroblast-…

P2X ion channels have been functionally characterized from a range of eukaryotes. Although
these receptors can be broadly classified into fast and slow desensitizing, the molecular …

Mammals deploy a large array of odorant receptors ( OR s) to detect and distinguish a vast
number of odorant molecules. OR s vary widely in the type of odorant structures recognized …

Pharmacological characterisation of a P2X receptor cloned from the central nervous system
of Lymnaea stagnalis.

Heteromeric α3β4 nicotinic acetylcholine (ACh) receptors (nAChRs) are pentameric ligand-gated
cation channels that include at least two α3 and two β4 subunits. They have functions …