… Sergio Emanuel Kaiser Engage, Alecardio, RED-HF, Odissey-Outcomes, SELECT
Amgen, Novo Nordisk, Novartis, astrazeneca, Momenta Farma, Daiichi-Sankyo, Pfizer …

Background The expression of carcino-embryonic antigen by colorectal cancer is an example
of oncogenic activation of embryonic gene expression. Hypothesizing that oncogenesis-…

… Rothenberg MD, PhD a , Ting Wen PhD a , Allison Greenberg BA a b , Oral Alpan MD c ,
Benjamin Enav MD c d , Ikuo Hirano MD e , Kari Nadeau MD, PhD f , Sergio Kaiser PhD g , …

Level of evidence Level A Data obtained from multiple concordant large randomized trials
and/or robust meta-analysis of randomized clinical trials Level B Data obtained from less …

The modulation of striatal dopamine release by presynaptic nicotinic acetylcholine receptors
is well documented for both synaptosomes and slices. Because the latter retain local …

Nicotinic agonists elicit the release of dopamine from striatal synaptosomes by acting on
presynaptic nicotinic acetylcholine receptors (nAChRs) on dopamine nerve terminals. Both α3β2…

Malignant peripheral nerve sheath tumors (MPNST) are highly invasive soft tissue sarcomas
that arise within the peripheral nerve and frequently metastasize. To identify molecular …

Understanding the biological pathways critical for common neurofibromatosis type 1 (NF1)
peripheral nerve tumours is essential, as there is a lack of tumour biomarkers, prognostic …

Presynaptic nicotinic acetylcholine receptors (nAChRs) on striatal synaptosomes stimulate
dopamine release. Partial inhibition by the α3β2-selective α-conotoxin-MII indicates …

The pathogenesis and clinical heterogeneity of Parkinson’s disease (PD) have been
evaluated from molecular, pathophysiological, and clinical perspectives. High-throughput …