User profiles for Shannon M. Reilly

Shannon Reilly

Weill Cornell Medicine
Verified email at med.cornell.edu
Cited by 4737

Adapting to obesity with adipose tissue inflammation

SM Reilly, AR Saltiel - Nature Reviews Endocrinology, 2017 - nature.com
Adipose tissue not only has an important role in the storage of excess nutrients but also
senses nutrient status and regulates energy mobilization. An overall positive energy balance is …

[PDF][PDF] Adipocyte-derived Th2 cytokines and myeloid PPARδ regulate macrophage polarization and insulin sensitivity

K Kang, SM Reilly, V Karabacak, MR Gangl… - Cell metabolism, 2008 - cell.com
The polarization of adipose tissue-resident macrophages toward the alternatively activated,
anti-inflammatory M2 phenotype is believed to improve insulin sensitivity. However, the …

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

S Fang, JM Suh, SM Reilly, E Yu, O Osborn… - Nature medicine, 2015 - nature.com
The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to
promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic …

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

SM Reilly, SH Chiang, SJ Decker, L Chang, M Uhm… - Nature medicine, 2013 - nature.com
Emerging evidence suggests that inflammation provides a link between obesity and insulin
resistance. The noncanonical IκB kinases IKK-ɛ and TANK-binding kinase 1 (TBK1) are …

[PDF][PDF] TBK1 at the crossroads of inflammation and energy homeostasis in adipose tissue

P Zhao, X Sun, SM Reilly, M Uhm, Z Liao… - Cell, 2018 - cell.com
The noncanonical IKK family member TANK-binding kinase 1 (TBK1) is activated by pro-inflammatory
cytokines, but its role in controlling metabolism remains unclear. Here, we report …

[HTML][HTML] PPARδ as a therapeutic target in metabolic disease

SM Reilly, CH Lee - FEBS letters, 2008 - Elsevier
PPARδ is the only member in the PPAR subfamily of nuclear receptors that is not a target of
current drugs. Animal studies demonstrate PPARδ activation exerts many favorable effects, …

[PDF][PDF] Inhibition of IKKɛ and TBK1 improves glucose control in a subset of patients with type 2 diabetes

…, M Jain, R Yu, C Liddle, M Ahmadian, M Downes… - Cell metabolism, 2017 - cell.com
Numerous studies indicate an inflammatory link between obesity and type 2 diabetes. The
inflammatory kinases IKKɛ and TBK1 are elevated in obesity; their inhibition in obese mice …

[HTML][HTML] Role of peroxisome proliferator-activated receptor δ/β in hepatic metabolic regulation

…, B Hatano, M Zhao, CC Yen, K Kang, SM Reilly… - Journal of Biological …, 2011 - ASBMB
Pharmacological activation of peroxisome proliferator-activated receptor δ/β (PPARδ/β)
improves glucose handling and insulin sensitivity. The target tissues of drug actions remain …

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

J Mowers, M Uhm, SM Reilly, J Simon, D Leto… - Elife, 2013 - elifesciences.org
10.7554/eLife.01119.001 Obesity produces a chronic inflammatory state involving the NFκB
pathway, resulting in persistent elevation of the noncanonical IκB kinases IKKε and TBK1. In …

[PDF][PDF] FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

M Abu-Odeh, Y Zhang, SM Reilly, N Ebadat, O Keinan… - Cell reports, 2021 - cell.com
The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show
that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires …