Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake
inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study …

Toll-like receptors (TLRs) are a major class of pattern recognition receptors, which mediate
the responses of innate immune cells to microbial stimuli. To systematically determine the …

Nuclear factor kappa-B (NF-κB) is a key transcription factor in the regulation of the innate
immune inflammatory response in activated macrophages. NF-κB functions as a homo- or …

Noncanonical inflammasome activation by cytosolic lipopolysaccharide (LPS) is a critical
component of the host response to Gram-negative bacteria. Cytosolic LPS recognition in …

Systems modeling is emerging as a valuable tool in therapeutics. This is seen by the increasing
use of clinically relevant computational models and a rise in systems biology companies …

Salmeterol is a long-acting β2-adrenergic receptor (β2AR) agonist that is widely used as a
bronchodilator for the treatment of persistent asthma and chronic obstructive pulmonary …

Models in biology have a long and distinguished history. By far the most common form of
biological model is the word model, where abstractions of many observations are simply stated …

We developed a unified model of the GRK-mediated β2 adrenergic receptor (β2AR) regulation
that simultaneously accounts for six different biochemical measurements of the system …

Functional understanding of signaling pathways requires detailed information about the
constituent molecules and their interactions. Simulations of signaling pathways therefore build …

Severe bacterial infection can lead to inflammation, host tissue damage, and ultimately
disseminated septic shock. The mammalian innate immune system responds to microbial …