Fipamezole (JP‐1730) is a potent α2 adrenergic receptor antagonist that reduces levodopa‐induced dyskinesia in the MPTP‐lesioned primate model of Parkinson's …

…, M Engstrom, H Merivuori, S Wurster… - … : official journal of the …, 2003 - Wiley Online Library
Previous studies in the MPTP‐lesioned primate model of Parkinson's disease have
demonstrated that α 2 adrenergic receptor antagonists such as idazoxan, rauwolscine, and …

Prolactin releasing peptide has high affinity and efficacy at neuropeptide FF2 receptors

M Engström, A Brandt, S Wurster, JM Savola… - Journal of Pharmacology …, 2003 - ASPET
Neuropeptide FF (NPFF) and prolactin-releasing peptide (PrRP) are two members of the
RFamide peptide family. In this study we investigated whether these RFamide peptides, which …

Analgesic effects of the somatostatin sst4 receptor selective agonist J-2156 in acute and chronic pain models

…, Á Szabó, E Pintér, M Engström, S Wurster… - European journal of …, 2006 - Elsevier
Somatostatin released from capsaicin-sensitive afferents exerts systemic anti-nociceptive
actions, presumably via somatostatin receptor subtype 4 (sst 4 ). In the present study, the …

Conserved structural, pharmacological and functional properties among the three human and five zebrafish α2‐adrenoceptors

…, VV Rantanen, K Vuoriluoto, S Wurster… - British journal of …, 2005 - Wiley Online Library
1 Zebrafish has five distinct α 2 ‐adrenoceptors. Two of these, α 2Da and α 2Db , represent a
duplicated, fourth α 2 ‐adrenoceptor subtype, while the others are orthologue of the human …

Molecular mechanism for agonist-promoted α2A-adrenoceptor activation by norepinephrine and epinephrine

…, AM Hoffrén, M Varis, T Salminen, S Wurster… - Molecular …, 2001 - ASPET
We present a mechanism for agonist-promoted α 2A -adrenergic receptor (α 2A -AR)
activation based on structural, pharmacological, and theoretical evidence of the interactions …

Structure−Activity Relationship of Quinoline Derivatives as Potent and Selective α2C-Adrenoceptor Antagonists

…, J Sallinen, JM Savola, S Wurster… - Journal of medicinal …, 2006 - ACS Publications
Starting from two acridine compounds identified in a high-throughput screening campaign (1
and 2, Table 1), a series of 4-aminoquinolines was synthesized and tested for their …

Superagonism at the human somatostatin receptor subtype 4

…, K El-Darwish, M Åhman, JM Savola, S Wurster - … of Pharmacology and …, 2005 - ASPET
We have discovered a novel compound, J-2156 [(1′S, 2S)-4-amino-N-(1′-carbamoyl-2′-phenylethyl)-2-(4″-methyl-1″-naphthalenesulfonylamino)butanamide],
that belongs to a …

Protean agonism at α2A-adrenoceptors

…, JP Kukkonen, J Näsman, GE Huifang, S Wurster… - Molecular …, 1998 - ASPET
The coupling of the endogenously expressed α 2A -adrenoceptors in human erythroleukemia
cells (HEL 92.1.7) to Ca 2+ mobilization and inhibition of forskolin-stimulated cAMP …

Effects of botulinum A toxin on presynaptic modulation of evoked transmitter release

R Nakov, E Habermann, G Hertting, S Wurster… - European journal of …, 1989 - Elsevier
A possible influence of botulinum A toxin on the modulation of evoked neurotransmitter release
was investigated in hippocampus tissue. Rabbit hippocampal slices prelabelled with [ 3 H…

Molecular mechanisms of ligand–receptor interactions in transmembrane domain V of the α2A‐adrenoceptor

JM Peltonen, T Nyrönen, S Wurster… - British journal of …, 2003 - Wiley Online Library
The structural determinants of catechol hydroxyl interactions with adrenergic receptors were
examined using 12 α 2 ‐adrenergic agonists and a panel of mutated human α 2A ‐…