The leukotrienes and lipoxins are biologically active metabolites derived from arachidonic
acid. Their diverse and potent actions are associated with specific receptors. Recent …

The aim of this work was to evaluate the role of leukotrienes in brain damage in vivo in a
model of focal cerebral ischaemia in the rat, obtained by permanent occlusion of middle …

Variations in the cytosolic free Ca2+ concentration [( Ca2+]i) upon LPS exposure were
studied in single rat peritoneal macrophages loaded with fura-2 under carefully controlled …

This study was aimed at characterizing ATP-induced rises in cytosolic free calcium ion,[Ca
2+] i, in a population of rat striatal astrocytes loaded with the fluorescent Ca 2+ probe Fura2 …

… Simonetta Nicosia. This model can account for both an apparent reduction in efficacy and
the curvature of the upper plateau of some concentration-response curves. Therefore, under …

Adenylate cyclase in liver membranes was solubilized with Lubrol PX and partially purified
by gel filtration. The partially purified enzyme was susceptible to activation by guanyl-5'-yl …

… This paper is specially dedicated to the memory of our mentor Simonetta Nicosia. Her
open-minded and critical approach to experimental work will always remain a guiding principle for …

In this study, we report the preparation of [3H]glucagon and its characteristics of binding to
receptors in the rat liver plasma membrane. Binding of the labeled hormone is optimal at pH …

We have previously reported, by means of equilibrium binding studies, the existence of two
distinct binding sites with receptor characteristics for LTC 4 and LTD 4 in human lung …

VIP stimulated adenylate cyclase activity in homogenates of some areas of rat brain that are
rich in this peptide, eg, cerebral cortex, hypothalamus and hippocampus, as well as in …