User profiles for Simrat P. S. Saini

Simrat Saini

Guru Angad Dev Veterinary Animal Sciences University, University of Pittsburgh, PA
Verified email at gadvasu.in
Cited by 1600

Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism

W Xie, H Uppal, SPS Saini, Y Mu, JM Little… - Drug discovery today, 2004 - Elsevier
The regulation of drug-metabolizing enzymes and transporters has an important role in drug
metabolism and many human diseases. The genes that encode these enzymes and …

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

…, A Radominska-Pandya, SPS Saini… - Proceedings of the …, 2003 - National Acad Sciences
Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase
1A (UGT1) gene encodes at least eight differently regulated mRNAs whose protein products …

A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

SPS Saini, J Sonoda, L Xu, D Toma, H Uppal… - Molecular …, 2004 - ASPET
Cytosolic sulfotransferase (SULT)-mediated sulfation plays an essential role in the detoxification
of bile acids and is necessary to avoid pathological conditions, such as cholestasis, …

[PDF][PDF] Activation of LXRs prevents bile acid toxicity and cholestasis in female mice

H Uppal, SPS Saini, A Moschetta, Y Mu, J Zhou… - …, 2007 - Wiley Online Library
Liver X receptors (LXRs) have been identified as sterol sensors that regulate cholesterol and
lipid homeostasis and macrophage functions. In this study, we found that LXRs also affect …

Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells

…, SP Singh, Y Mu, JH Lee, SPS Saini… - Molecular …, 2006 - academic.oup.com
Efficient handling of oxidative stress is critical for the survival of organisms. The orphan nuclear
receptor pregnane X receptor (PXR) is important in xenobiotic detoxification through its …

[PDF][PDF] Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice

H Uppal, D Toma, SPS Saini, S Ren, TJ Jones… - …, 2005 - Wiley Online Library
Efficient detoxification of bile acids is necessary to avoid pathological conditions such as
cholestatic liver damage and colon cancer. The orphan nuclear receptors PXR and CAR have …

[PDF][PDF] Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice

SPS Saini, Y Mu, H Gong, D Toma, H Uppal… - …, 2005 - Wiley Online Library
The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are implicated
in xenobiotic and endobiotic detoxification, including the clearance of toxic bilirubin. …

[PDF][PDF] Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice

SPS Saini, B Zhang, Y Niu, M Jiang, J Gao, Y Zhai… - …, 2011 - Wiley Online Library
Overdose of acetaminophen (APAP), the active ingredient of Tylenol, is the leading cause of
drug‐induced acute liver failure in the United States. As such, it is necessary to develop …

A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development

Y Mu, CRJ Stephenson, C Kendall, SPS Saini… - Molecular …, 2005 - ASPET
Pregnane X receptor (PXR) is an orphan nuclear receptor that regulates the expression of
genes encoding drug-metabolizing enzymes and transporters. In addition to affecting drug …

Carbamate Pesticide Carbaryl Induces Alterations in Antioxidant and Oxidative Stress Related Responses of Indian Buffalo (Bubalus bubalis) after Sub-Chronic …

…, R Kaur, SS Gouri, VK Dumka, SPS Saini - … Formerly Indian Journal …, 2017 - ischolar.sscldl.in
The aim of the present work was to study the alterations of the antioxidant defenses and the
overall susceptibility to oxidative stress of the Bubalus bubalis exposed to the carbamate …