The progression of cancers from primary tumors to invasive and metastatic stages accounts
for the overwhelming majority of cancer deaths. Understanding the molecular events which …

Melanoma is the deadliest form of skin cancer. Although targeted therapies and immunotherapies
have revolutionized the treatment of metastatic melanoma, most patients are not cured…

Cells can rapidly adjust their proteomes in dynamic environments by regulating mRNA
translation. There is mounting evidence that dysregulation of mRNA translation supports the …

Melanoma is an immunogenic cancer with a high response rate to immune checkpoint
inhibitors (ICIs). It harbors a high mutation burden compared with other cancers and, as a result, …

Cancer is irrevocably linked to aberrant metabolic processes. While once considered a
vestigial organelle, we now know that peroxisomes play a central role in the metabolism of …

Stats (signal transducers and activators of transcription) are latent cytoplasmic transcription
factors that on a specific stimulus migrate to the nucleus and exert their transcriptional activity…

The translation of mRNAs into proteins serves as a critical regulatory event in gene
expression. In the context of cancer, deregulated translation is a hallmark of transformation, …

CCCTC-binding factor (CTCF) is a key regulator of nuclear chromatin structure and gene
regulation. The impact of CTCF on transcriptional output is highly varied, ranging from …

The translation initiation factor eIF4E is an oncogene that is commonly overexpressed in
primary breast cancers and metastases. In this article, we report that a pharmacologic inhibitor …

This study investigates the MNK1/2–eIF4E signaling axis in tumor and stromal cells in metastatic
breast cancer and reveals that MNK1/2 inhibition suppresses metastasis and sensitizes …