The heterotrimeric G-protein G s couples cell-surface receptors to the activation of adenylyl
cyclases and cyclic AMP production (reviewed in refs 1 , 2 ). RGS proteins, which act as …

Regulators of G-protein signaling (RGS) proteins enhance the intrinsic rate at which certain
heterotrimeric G-protein α-subunits hydrolyze GTP to GDP, thereby limiting the duration that α…

The production of cAMP is controlled on many levels, notably at the level of cAMP synthesis
by the enzyme adenylyl cyclase. We have recently identified a new regulator of adenylyl …

Sonic hedgehog (Shh) is a secreted morphogen crucial for cell fate decision, cellular
proliferation, and patterning during vertebrate development. The intracellular Shh signalling is …

Regulator of G-protein signaling 3 (RGS3) enhances the intrinsic rate at which Gα i and Gα
q hydrolyze GTP to GDP, thereby limiting the duration in which GTP-Gα i and GTP-Gα q can …

Many Regulators of G proteinSignaling (RGS) proteins accelerate the intrinsic GTPase activity
of G iα and G qα -subunits [ie, behave as GTPase-activating proteins (GAPs)] and several …

G 12 α/G 13 α transduces signals from G-protein-coupled receptors to stimulate growth-promoting
pathways and the early response gene c-fos. Within the c-fos promoter lies a key …

Ampakines are small benzamide compounds that allosterically produce the positive modulation
of AMPA receptors and improve performance on a variety of behavioral tasks. To test if …

… SRIKUMAR SINNARAJAH,1 VISHNU SUPPIRAMANIAM,2 KOLAPPA PREM KUMAR,2 …
Hall RA, Vodyanoy V, Quan A, Sinnarajah S, Suppiramaniam V, Kessler M, Bahr BA. 1996b. …

Heparin was found to bind to α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)
receptors and to alter their functional properties. AMPA receptors solubilized in 0.4% Triton …