Cutaneous melanoma represents the most aggressive form of skin cancer, whereas vitiligo
is an autoimmune disorder that leads to progressive destruction of skin melanocytes. …

We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …

Postreplicative mismatch repair plays a major role in mediating the cytotoxicity of agents
generatingO 6 -methylguanine in DNA. We previously showed that a methylating antitumor …

The mammalian mismatch repair (MMR) system has been implicated in activation of the G 2
checkpoint induced by methylating agents. In an attempt to identify the signaling events …

The action of Lonidamine [1-(2,4-dichlorobenzyl)-1-H-indazol-3-carboxylic acid] on oxygen
consumption and the rate of aerobic and anaerobic lactate production by Ehrlich ascites …

In human epidermal keratinocytes, replicative senescence, is determined by a progressive
decline of clonogenic and dividing cells. Its timing is controlled by clonal evolution, that is, by …

The vascular endothelial growth factor is produced by a large variety of human tumors,
including melanoma, in which it appears to play an important role in the process of tumor-induced …

The use of IFN-α in clinical oncology has generally been based on the rationale of exploiting
its antiproliferative and antiangiogenic activities. However, IFN-α also exhibits enhancing …

Background Microenvironment cues involved in melanoma progression are largely unknown.
Melanoma is highly influenced in its aggressive phenotype by the changes it determinates …

The SKI protein is a transcriptional coregulator over‐expressed in melanoma. Experimentally
induced down‐regulation of SKI inhibits melanoma cell growth in vitro and in vivo. …