Nociception is essential for survival whereas pathological pain is maladaptive and often
unresponsive to pharmacotherapy. Voltage-gated sodium channels, Na v 1.1–Na v 1.9, are …

Traumatic spinal cord injury (SCI) results not only in motor impairment but also in chronic
central pain, which can be refractory to conventional treatment approaches. It has been shown …

1. In situ hybridization with subtype-specific probes was used to ask whether there is a
change in the types of sodium channels that are expressed in dorsal root ganglion (DRG) …

The voltage-gated sodium channel Na V 1.7 is preferentially expressed in peripheral
somatic and visceral sensory neurons, olfactory sensory neurons and sympathetic ganglion …

The family of voltage-gated sodium channels initiates action potentials in all types of excitable
cells. Nine members of the voltage-gated sodium channel family have been characterized …

White matter of the mammalian CNS suffers irreversible injury when subjected to anoxia/ischemia.
However, the mechanisms of anoxic injury in central myelinated tracts are not well …

This article reviews the determinants of conduction velocity in myelinated nerve fibers. For
fibers exhibiting geometric similarity, conduction velocity is nearly proportional to diameter. …

Objective: Small nerve fiber neuropathy (SFN) often occurs without apparent cause, but no
systematic genetic studies have been performed in patients with idiopathic SFN (I‐SFN). We …

Transplantation of human mesenchymal stem cells has been shown to reduce infarct size
and improve functional outcome in animal models of stroke. Here, we report a study designed …

C-type dorsal root ganglion (DRG) neurons can generate tetrodotoxin-resistant (TTX-R)
sodium-dependent action potentials. However, multiple sodium channels are expressed in these …