Previous research has suggested that human herpesvirus-6 (HHV-6) may integrate into
host cell chromosomes and be vertically transmitted in the germ line, but the evidence—primarily …

Benzodiazepines (BZs) act on γ-aminobutyric acid type A (GABA A) receptors such as α 1 β
2 γ 2 through key residues within the N-terminal region of α subunits, to render their sedative …

Phencyclidine (PCP) and ketamine are dissociative anesthetics capable of inducing
analgesia, psychomimetic behavior, and a catatonic state of unconsciousness. Despite broad …

Vagal afferent sensory nerves, originating in jugular and nodose ganglia, are composed of
functionally distinct subsets whose activation evokes distinct thoracic and abdominal reflex …

Mitochondrial dysfunction and subsequent oxidative stress has been reported for a variety of
cell types in inflammatory diseases. Given the abundance of mitochondria at the peripheral …

The airways are densely innervated by sensory afferent nerves, whose activation regulates
respiration and triggers defensive reflexes (eg, cough, bronchospasm). Airway innervation is …

The onset of motor learning in rats coincides with exclusive expression of GABA A receptors
containing α 6 and δ subunits in the granule neurons of the cerebellum. This development …

Transient receptor potential ankyrin 1 (TRPA1) is a polymodal cation channel that is activated
by electrophilic irritants, oxidative stress, cold temperature, and GPCR signaling. TRPA1 …

Inflammation causes activation of nociceptive sensory nerves, resulting in debilitating
sensations and reflexes. Inflammation also induces mitochondrial dysfunction through multiple …

Airway sensory nerve excitability is a key determinant of respiratory disease-associated
reflexes and sensations such as cough and dyspnea. Inflammatory signaling modulates …