Recent studies on mutations in cancer genomes have distinguished driver mutations from
passenger mutations, which occur as byproducts of cancer development. The cancer genome …

Under low oxygen tension, cells increase the transcription of specific genes involved in
angiogenesis, erythropoiesis, and glycolysis. Hypoxia-induced gene expression depends …

Hypoxia-inducible factor-1 (HIF-1) is a transcription factor involved in the cancer cell adaptation
to hypoxia, a leading cause of tumor malignancy. Thus, control of HIF-1α expression may …

At a low-oxygen tension, cells increase the expression of several genes (such as erythropoietin,
the vascular endothelial growth factor, and glycolytic enzymes) in order to adapt to …

Wnt5a, a prototypic non-canonical Wnt, is an inflammatory factor elevated in the sera of
obese humans and mice. In the present study, fat-specific knockout of Wnt5a (Wnt5a-FKO) …

Changes in the respiratory system caused by aging generally include structural changes in
the thoracic cage and lung parenchyma, abnormal findings on lung function tests, ventilation …

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces expression of the cytochrome P450
1A1 gene, cyp1a1, by binding to its receptor, aryl hydrocarbon receptor (AhR). TCDD-bound …

Both hypoxia and insulin induce common target genes, including vascular endothelial growth
factors and several glycolytic enzymes. However, these two signals eventually trigger quite …

Clioquinol (CQ) is a hypoxic mimicker to activate hypoxia-inducible factor-1α (HIF-1α) by
inhibiting HIF-1α specific asparaginyl hypoxylase (FIH-1). The structural similarity of the Jumonji …

In this study, oil palm biomass such as empty fruit bunch (EFB) and palm kernel shell (PKS)
was used as raw materials for making pellets. Hardwood sawdusts were also mixed with …