Human lysosomal acid lipase (hLAL) is essential for the hydrolysis of cholesteryl esters and
triglycerides in the lysosome. Defective hLAL activity leads to two autosomal recessive traits, …

Previous neuroimaging studies have detected markers of neuroinflammation in patients
with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Magnetic Resonance …

Lysosomal acid lipase (LAL) is essential for the hydrolysis of cholesterol esters and triglycerides
that are delivered to the lysosomes via the low density lipoprotein receptor system. The …

Introduction Accurate grading of cerebral glioma using conventional structural imaging
techniques remains challenging due to the relatively poor sensitivity and specificity of these …

Abstract Knowledge of physiological aging in healthy human brain is increasingly important
for neuroscientific research and clinical diagnosis. To investigate neuronal decline in normal …

Purpose MRSI has shown great promise in the detection and monitoring of neurologic
pathologies such as tumor. A necessary component of data processing includes the quantitation …

Glutamate (Glu) and glutamine (Gln) play an important role in neuronal regulation and are of
value as MRS‐observable diagnostic biomarkers. In this study the relative concentrations of …

Purpose To assess volumetric proton MR spectroscopic imaging (MRSI) of the human brain
on multivendor MRI instruments. Methods Echo‐planar spectroscopic imaging was …

Purpose A feasibility study of an echo‐planar spectroscopic imaging (EPSI) using a short
echo time (TE) that trades off sensitivity, compared with other short‐TE methods, to achieve …

The incidence of early-onset colorectal cancer (EO-CRC) is rising and is poorly understood.
Lifestyle factors and altered genetic background possibly contribute. Here, we performed …