1α,25-Dihydroxyvitamin D 3 [1,25-(OH) 2 D 3 ], the active metabolite of vitamin D 3 , is known
for the maintenance of mineral homeostasis and normal skeletal architecture. However, …

The major heat-stable shrimp allergen (designated as Sa-II), capable of provoking IgE-mediated
immediate type hypersensitivity reactions after the ingestion of cooked shrimp, has …

Retinoids exert their biologic effects through two families of nuclear receptors, retinoic acid
receptors (RARs) and retinoid X receptors (RXRs), which belong to the superfamily of …

The magnesium transporter 1 (MAGT1) is a critical regulator of basal intracellular free
magnesium (Mg 2+ ) concentrations. Individuals with genetic deficiencies in MAGT1 have high …

By regulating activities and expression levels of key signaling molecules, estrogens control
mechanisms that are responsible for crucial cellular functions. Ligand binding to estrogen …

We have previously reported that the AB regions of retinoic acid receptors (RARs and RXRs)
contain a transcriptional activation function capable of modulating the activity of the ligand‐…

Retinoids, synthetic and natural analogs of retinoic acid, exhibit potent growth inhibitory and
cell differentiation activities that account for their beneficial effects in treating …

Background MYC gene rearrangement is present in approximately 10% of aggressive B-cell
lymphomas, with half also harbouring a BCL2 gene rearrangement. Multiple retrospective …

Increased protein citrullination is linked to various diseases including rheumatoid arthritis (RA),
lupus, and cancer. Citrullinated autoantigens, a hallmark of RA, are recognized by anti-…

Psoriasis is a chronic immune-mediated disease that is characterized by the hyperproliferation
and abnormal differentiation of keratinocytes and by inflammation. The epidermal …