[HTML][HTML] Negative regulation of cytochrome c‐mediated oligomerization of Apaf‐1 and activation of procaspase‐9 by heat shock protein 90
…, C Nalin, ES Alnemri, D Kufe, S Kharbanda - The EMBO …, 2000 - embopress.org
The release of cytochrome c from mitochondria results in the formation of an Apaf‐1–caspase‐9
apoptosome and induces the apoptotic protease cascade by activation of procaspase‐3…
apoptosome and induces the apoptotic protease cascade by activation of procaspase‐3…
Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy
…, R Virmani, S Saxena, S Kharbanda - Proceedings of the …, 1999 - National Acad Sciences
Apoptosis has been shown to contribute to loss of cardiomyocytes in cardiomyopathy,
progressive decline in left ventricular function, and congestive heart failure. Because the …
progressive decline in left ventricular function, and congestive heart failure. Because the …
p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage
…, T Ishiko, X Sun, J Gu, YY Huang, H Lu, S Kharbanda… - Nature, 1999 - nature.com
The protein p73 is a structural and functional homologue of the p53 tumour-suppressor protein
but, unlike p53, it is not induced in response to DNA damage 1 , 2 . The tyrosine kinase c-…
but, unlike p53, it is not induced in response to DNA damage 1 , 2 . The tyrosine kinase c-…
Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents
S Kharbanda, R Ren, P Pandey, TD Shafman… - Nature, 1995 - nature.com
THE product of the c-abl gene is a non-receptor tyrosine kinase that is localized to the
nucleus and cytoplasm. The precise function of c-Abl is unknown. Here we show that ionizing …
nucleus and cytoplasm. The precise function of c-Abl is unknown. Here we show that ionizing …
Tumstatin, an endothelial cell-specific inhibitor of protein synthesis
…, A Sudhakar, JC Lively, K Ueki, S Kharbanda… - Science, 2002 - science.org
Tumstatin is a 28-kilodalton fragment of type IV collagen that displays both anti-angiogenic
and proapoptotic activity. Here we show that tumstatin functions as an endothelial cell–…
and proapoptotic activity. Here we show that tumstatin functions as an endothelial cell–…
[HTML][HTML] Translocation of SAPK/JNK to mitochondria and interaction with Bcl-xL in response to DNA damage
Activation of the stress-activated protein kinase (SAPK/JNK) by genotoxic agents is
necessary for induction of apoptosis. We report here that ionizing radiation ionizing radiation …
necessary for induction of apoptosis. We report here that ionizing radiation ionizing radiation …
Interaction between ATM protein and c-Abl in response to DNA damage
…, D Watters, M Egerton, Y Shiloh, S Kharbanda… - Nature, 1997 - nature.com
The gene mutated in the autosomal recessive disorder ataxia telangiectasia (AT),
designated ATM (for 'AT mutated'), is a member of a family of phosphatidylinositol-3-kinase-like …
designated ATM (for 'AT mutated'), is a member of a family of phosphatidylinositol-3-kinase-like …
Proteolytic activation of protein kinase C δ by an ICE/CED 3-like protease induces characteristics of apoptosis
…, P Pandey, R Datta, Y Huang, S Kharbanda… - The Journal of …, 1996 - rupress.org
Recent studies have shown that protein kinase C (PKC) δ is proteolytically activated at the
onset of apoptosis induced by DNA-damaging agents, tumor necrosis factor, and anti-Fas …
onset of apoptosis induced by DNA-damaging agents, tumor necrosis factor, and anti-Fas …
Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis
S Kharbanda, P Pandey, L Schofield… - Proceedings of the …, 1997 - National Acad Sciences
Cytochrome C is a mitochondrial protein that induces apoptosis when released into the
cytosol or when added to cell-free extracts. Here we show that cells that overexpress the Bcl-2-…
cytosol or when added to cell-free extracts. Here we show that cells that overexpress the Bcl-2-…
Hsp27 functions as a negative regulator of cytochrome c-dependent activation of procaspase-3
…, C Nalin, R Weichselbaum, D Kufe, S Kharbanda - Oncogene, 2000 - nature.com
The release of mitochondrial cytochrome c by genotoxic stress induces the formation of a
cytosolic complex with Apaf-1 (mammalian CED4 homolog) and thereby the activation of …
cytosolic complex with Apaf-1 (mammalian CED4 homolog) and thereby the activation of …