The release of cytochrome c from mitochondria results in the formation of an Apaf‐1–caspase‐9
apoptosome and induces the apoptotic protease cascade by activation of procaspase‐3…

Apoptosis has been shown to contribute to loss of cardiomyocytes in cardiomyopathy,
progressive decline in left ventricular function, and congestive heart failure. Because the …

The protein p73 is a structural and functional homologue of the p53 tumour-suppressor protein
but, unlike p53, it is not induced in response to DNA damage 1 , 2 . The tyrosine kinase c-…

THE product of the c-abl gene is a non-receptor tyrosine kinase that is localized to the
nucleus and cytoplasm. The precise function of c-Abl is unknown. Here we show that ionizing …

Tumstatin is a 28-kilodalton fragment of type IV collagen that displays both anti-angiogenic
and proapoptotic activity. Here we show that tumstatin functions as an endothelial cell–…

Activation of the stress-activated protein kinase (SAPK/JNK) by genotoxic agents is
necessary for induction of apoptosis. We report here that ionizing radiation ionizing radiation …

The gene mutated in the autosomal recessive disorder ataxia telangiectasia (AT),
designated ATM (for 'AT mutated'), is a member of a family of phosphatidylinositol-3-kinase-like …

Recent studies have shown that protein kinase C (PKC) δ is proteolytically activated at the
onset of apoptosis induced by DNA-damaging agents, tumor necrosis factor, and anti-Fas …

Cytochrome C is a mitochondrial protein that induces apoptosis when released into the
cytosol or when added to cell-free extracts. Here we show that cells that overexpress the Bcl-2-…

The release of mitochondrial cytochrome c by genotoxic stress induces the formation of a
cytosolic complex with Apaf-1 (mammalian CED4 homolog) and thereby the activation of …