Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment

SIV Judge, CT Bever Jr - Pharmacology & therapeutics, 2006 - Elsevier
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by demyelination, with a relative sparing of axons. In MS patients, many neurologic …

The voltage-gated potassium channel Kv1. 3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain

…, L Guo, H Wulff, C Beeton, SIV Judge… - Proceedings of the …, 2005 - National Acad Sciences
Multiple Sclerosis (MS) is characterized by central nervous system perivenular and
parenchymal mononuclear cell infiltrates consisting of activated T cells and macrophages. We …

Overexpression of SIRT1 protein in neurons protects against experimental autoimmune encephalomyelitis through activation of multiple SIRT1 targets

…, V Ahmad, NK Nagalla, D Trisler, SIV Judge… - The Journal of …, 2013 - journals.aai.org
Abstract Treatment of experimental autoimmune encephalomyelitis (EAE) with resveratrol,
an activator of sirtuin 1 (SIRT1), reduces disease severity. This suggested that activators of …

[PDF][PDF] Voltage-gated potassium channels in multiple sclerosis: Overview and new implications for treatment of central nervous system inflammation and degeneration.

SIV Judge, JM Lee, CT Bever Jr… - Journal of Rehabilitation …, 2006 - researchgate.net
Inflammatory tissue damage and the presence of reactive immunocompetent T lymphocytes,
macrophages, microglia, and dendritic cells (DCs) are characteristic features in the human …

Potassium channel blockers and openers as CNS neurologic therapeutic agents

SIV Judge, PJ Smith, PE Stewart… - Recent Patents on CNS …, 2007 - ingentaconnect.com
Potassium (K+) channels are the most heterogeneous and widely distributed class of ion
channels. K+ channels are dynamic pore-forming transmembrane proteins known to play …

Potassium channels Kv1.3 and Kv1.5 are expressed on blood‐derived dendritic cells in the central nervous system

…, MW Pennington, DC Johns, SIV Judge… - Annals of …, 2006 - Wiley Online Library
Objective Potassium (K + ) channels on immune cells have gained attention recently as
promising targets of therapy for immune‐mediated neurological diseases such as multiple …

Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides

…, JB King, JC Bopassa, SIV Judge… - Proceedings of the …, 2017 - National Acad Sciences
Mass-spectrometry-based metabolomics and molecular phylogeny data were used to identify
a metabolically prolific strain of Tolypocladium that was obtained from a deep-water Great …

TrkB agonist, 7, 8-dihydroxyflavone, reduces the clinical and pathological severity of a murine model of multiple sclerosis

…, IS Singh, K Lam, F Mubariz, SIV Judge… - Journal of …, 2016 - Elsevier
7,8-Dihydroxyflavone (DHF), is a recently described TrkB agonist that readily crosses the
blood brain barrier. We treated C57Bl/6 mice with MOG — induced EAE daily with DHF starting …

Sustained-release fampridine for multiple sclerosis

CT Bever Jr, SIV Judge - Expert opinion on investigational drugs, 2009 - Taylor & Francis
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central
nervous system of unknown cause in which neurological impairment and disability result …

C5b-9-activated, Kv1. 3 channels mediate oligodendrocyte cell cycle activation and dedifferentiation

…, A Khan, F Niculescu, V Rus, SIV Judge… - … and molecular pathology, 2011 - Elsevier
Voltage-gated potassium (K v ) channels play an important role in the regulation of growth
factor-induced cell proliferation. We have previously shown that cell cycle activation is …