VEGF164-mediated Inflammation Is Required for Pathological, but Not Physiological, Ischemia-induced Retinal Neovascularization

S Ishida, T Usui, K Yamashiro, Y Kaji… - The Journal of …, 2003 - rupress.org
Hypoxia-induced VEGF governs both physiological retinal vascular development and
pathological retinal neovascularization. In the current paper, the mechanisms of physiological and …

[HTML][HTML] VEGF164 is proinflammatory in the diabetic retina

S Ishida, T Usui, K Yamashiro, Y Kaji… - … & visual science, 2003 - arvojournals.org
purpose. The objectives of this study were to characterize the differential potency of two
major VEGF isoforms, VEGF 120 and VEGF 164, for inducing leukocyte stasis (leukostasis) …

Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells

T Koto, K Takubo, S Ishida, H Shinoda, M Inoue… - The American journal of …, 2007 - Elsevier
The mechanisms underlying the hypoxia-induced disruption of the barrier function of neural
vasculature were analyzed with reference to the expression of claudin-5, a component of …

Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease

S Ishida, K Yamashiro, T Usui, Y Kaji, Y Ogura… - Nature medicine, 2003 - nature.com
Retinal ischemia can cause vision-threatening pathological neovascularization. The
mechanisms of retinal ischemia are not fully understood, however. Here we have shown that …

[HTML][HTML] Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-κB pathway

…, M Inoue, K Tsubota, K Umezawa, S Ishida - … & visual science, 2007 - arvojournals.org
purpose. To investigate the involvement of the renin-angiotensin system (RAS) and the nuclear
factor (NF)-κB pathway with diabetes-induced retinal inflammation. methods. Six weeks …

Macular pigment lutein is antiinflammatory in preventing choroidal neovascularization

…, K Umezawa, S Ohno, Y Oike, S Ishida - … , and vascular biology, 2007 - Am Heart Assoc
Background— Choroidal neovascularization (CNV) is a critical pathogenesis in age-related
macular degeneration, the most common cause of blindness in the developed countries. …

[HTML][HTML] VEGF164 (165) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2

T Usui, S Ishida, K Yamashiro, Y Kaji… - … & visual science, 2004 - arvojournals.org
purpose. Vascular endothelial growth factor (VEGF) induces angiogenesis and vascular
permeability and is thought to be operative in several ocular vascular diseases. The VEGF …

[HTML][HTML] Neuroprotective effect of an antioxidant, lutein, during retinal inflammation

…, Y Imamura, S Kobayashi, S Ishida… - … & visual science, 2009 - iovs.arvojournals.org
purpose. Lutein has been the focus of recent study as a possible therapeutic approach for
retinal diseases, but the molecular mechanism of its neuroprotective effect remains to be …

[HTML][HTML] A significant role of stromal fibroblasts in rapidly progressive dry eye in patients with chronic GVHD

…, Y Mashima, Y Nakamura, S Ishida… - … & visual science, 2001 - arvojournals.org
purpose. To elucidate histopathologic features of the lacrimal gland in chronic graft-versus-host
disease (GVHD) after allogeneic hematopoietic stem cell transplantation. methods. …

[HTML][HTML] Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor–κB activation

…, K Noda, Y Ozawa, Y Oike, S Ishida… - … & visual science, 2009 - jov.arvojournals.org
purpose. Resveratrol is known as one of the antioxidant polyphenols contained in red wine
and grape skin. The purpose of the present study was to investigate the role of resveratrol in …