This review represents an update of the nomenclature system for the UDP glucuronosyltransferase
gene superfamily, which is based on divergent evolution. Since the previous review …

Glucuronidation represents a major pathway which enhances the elimination of many
lipophilic xenobiotics and endobiotics to more water-soluble compounds. The UDP-…

Over 20 years have elapsed since aspartame was approved by regulatory agencies as a
sweetener and flavor enhancer. The safety of aspartame and its metabolic constituents was …

… King, CD, MD Green, GR Rios, BL Coffman, IS Owens, WP Bishop, and TR Tephly. 1996.
The glucuronidation of exogenous and endogenous compounds by stably expressed rat and …

… 7.7), 2 mM nalorphine (pH 8.4), 2 mM naloxone (pH 7.7), 2 mM naltrexone (pH 7.0), and 0.5
mM buprenorphine (pH 7.0)] was assayed using the method described by Puig and Tephly (…

UGT2B7 has been cloned and expressed previously in COS cells and HK293 cells. Two
forms have been identified: one with a tyrosine and one with a histidine at position 268. …

… (15) and Tephly (18) demonstrated that the depletion of bicarbonate in methanol poisoned
monkeys occurred in a mole-for-mole fashion with the accumulation of formate. Apparently, …

… Recent advances in biochemical and molecular biological approaches, reviewed here by
Thomas Tephly and Brian Burchell, have given new insight into the function and structure of …

… McMartin KE, Martin-Amat G, Noker PE, Tephly TR: Lack of a role for formaldehvde in
methanol ooisoninrr in the monkey. Biochem Pharmacol1979; 28:645-649. -” Marc-Aurele J, …

Glucuronide conjugation of xenobiotics containing a tertiary amine moiety represents a
unique and important metabolic pathway for these compounds in humans. Previously, human …