… Harris, LC, Remack, JS, and Brent TP in vitro methylation of … Qian, X., vonWronski, MA,
and Brent, TP Localization of … vonWronski, MA, and Brent, TP Effect of 5-azacytidine on …

The activity of temozolomide combined with irinotecan (CPT-11) was evaluated against
eight independent xenografts (four neuroblastomas,three rhabdomyosarcomas, and one …

O 6 -methylguanine-DNA methyltransferase (MGMT)is a ubiquitous protein responsible for
repair of O 6 -alkylguanine, a mutagenic, carcinogenic and toxic lesion. To characterize the …

The antitumor activity of the methylating agent temozolomide has been evaluated against a
panel of 17 xenografts derived from pediatric solid tumors. Temozolomide was administered …

Expression of the cell surface receptor Fas is frequently lost or decreased during tumor
progression in human colon carcinomas. The methylation status of a 583 bp CpG-rich region …

Recombinant lambda phage DNA containing segments of human O 6 -methylguanine-DNA
transferase gene was employed to localize this gene among the human chromosomes using …

High-level expression of the DNA repair protein O 6 -methylguanine-DNA methyltransferase
(MGMT) correlates with cellular resistance to the chloroethylnitrosourea (CENU) class of …

Background: Alkylating N-nitroso compounds can interact directly with DNA, forming O 6 -alkylguanine,
a DNA adduct proved to be mutagenic and carcinogenic if not sufficiently …

… Tom Brent for his support and excellent guidance over the years. Dr. Brent has now retired
after 40 years of research. All of the oligonucleotides were synthesized by the Hartwell Center …

✓ The level of O 6 -alkylguanine-deoxyribonucleic acid (DNA) alkyltransferase (AT) was
determined in 15 human brain-tumor xenografts in athymic mice. This enzyme is a primary …