User profiles for T. T. Talley
Todd TalleyVerified email at ucsd.edu Cited by 2475 |
Crystal structure of a Cbtx–AChBP complex reveals essential interactions between snake α‐neurotoxins and nicotinic receptors
The crystal structure of the snake long α‐neurotoxin, α‐cobratoxin, bound to the pentameric
acetylcholine‐binding protein (AChBP) from Lymnaea stagnalis, was solved from good …
acetylcholine‐binding protein (AChBP) from Lymnaea stagnalis, was solved from good …
Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism
Spirolide and gymnodimine macrocyclic imine phycotoxins belong to an emerging class of
chemical agents associated with marine algal blooms and shellfish toxicity. Analysis of 13-…
chemical agents associated with marine algal blooms and shellfish toxicity. Analysis of 13-…
Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor
The pentameric acetylcholine‐binding protein (AChBP) is a soluble surrogate of the ligand
binding domain of nicotinic acetylcholine receptors. Agonists bind within a nest of aromatic …
binding domain of nicotinic acetylcholine receptors. Agonists bind within a nest of aromatic …
Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore
Acetylcholine-binding proteins (AChBPs) from mollusks are suitable structural and functional
surrogates of the nicotinic acetylcholine receptors when combined with transmembrane …
surrogates of the nicotinic acetylcholine receptors when combined with transmembrane …
[HTML][HTML] Structural and ligand recognition characteristics of an acetylcholine-binding protein from Aplysia californica
We generated an acetylcholine-binding protein from Aplysia californica by synthesis of a
cDNA found in existing data bases and its expression in mammalian cell culture. Its subunit …
cDNA found in existing data bases and its expression in mammalian cell culture. Its subunit …
Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template
Nicotinic acetylcholine receptors (nAChRs), which are responsible for mediating key physiological
functions, are ubiquitous in the central and peripheral nervous systems. As members …
functions, are ubiquitous in the central and peripheral nervous systems. As members …
Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes
Neuronal nicotinic receptors, encoded by nine genes of the α and three of the β type of subunits,
and whose gene products assemble in distinct permutations as pentameric molecules, …
and whose gene products assemble in distinct permutations as pentameric molecules, …
[HTML][HTML] Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein
The recent characterization of an acetylcholine binding protein (AChBP) from the fresh water
snail, Lymnaea stagnalis, shows it to be a structural homolog of the extracellular domain of …
snail, Lymnaea stagnalis, shows it to be a structural homolog of the extracellular domain of …
Mapping the elusive neonicotinoid binding site
M Tomizawa, TT Talley, D Maltby… - Proceedings of the …, 2007 - National Acad Sciences
Two types of structurally similar nicotinic agonists have very different biological and
physicochemical properties. Neonicotinoids, important insecticides including imidacloprid and …
physicochemical properties. Neonicotinoids, important insecticides including imidacloprid and …
Atypical nicotinic agonist bound conformations conferring subtype selectivity
M Tomizawa, D Maltby, TT Talley… - Proceedings of the …, 2008 - National Acad Sciences
The nicotinic acetylcholine (ACh) receptor (nAChR) plays a crucial role in excitatory
neurotransmission and is an important target for drugs and insecticides. Diverse nAChR subtypes …
neurotransmission and is an important target for drugs and insecticides. Diverse nAChR subtypes …