User profiles for T. T. Talley

Todd Talley

Verified email at ucsd.edu
Cited by 2475

Crystal structure of a Cbtx–AChBP complex reveals essential interactions between snake α‐neurotoxins and nicotinic receptors

Y Bourne, TT Talley, SB Hansen, P Taylor… - The EMBO …, 2005 - embopress.org
The crystal structure of the snake long α‐neurotoxin, α‐cobratoxin, bound to the pentameric
acetylcholine‐binding protein (AChBP) from Lymnaea stagnalis, was solved from good …

Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism

Y Bourne, Z Radić, R Aráoz, TT Talley… - Proceedings of the …, 2010 - National Acad Sciences
Spirolide and gymnodimine macrocyclic imine phycotoxins belong to an emerging class of
chemical agents associated with marine algal blooms and shellfish toxicity. Analysis of 13-…

Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

RE Hibbs, G Sulzenbacher, J Shi, TT Talley… - The EMBO …, 2009 - embopress.org
The pentameric acetylcholine‐binding protein (AChBP) is a soluble surrogate of the ligand
binding domain of nicotinic acetylcholine receptors. Agonists bind within a nest of aromatic …

Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore

TT Talley, M Harel, RE Hibbs, Z Radić… - Proceedings of the …, 2008 - National Acad Sciences
Acetylcholine-binding proteins (AChBPs) from mollusks are suitable structural and functional
surrogates of the nicotinic acetylcholine receptors when combined with transmembrane …

[HTML][HTML] Structural and ligand recognition characteristics of an acetylcholine-binding protein from Aplysia californica

SB Hansen, TT Talley, Z Radic, P Taylor - Journal of Biological Chemistry, 2004 - ASBMB
We generated an acetylcholine-binding protein from Aplysia californica by synthesis of a
cDNA found in existing data bases and its expression in mammalian cell culture. Its subunit …

Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template

…, B Stump, JR Fotsing, T Weide, TT Talley… - Journal of the …, 2012 - ACS Publications
Nicotinic acetylcholine receptors (nAChRs), which are responsible for mediating key physiological
functions, are ubiquitous in the central and peripheral nervous systems. As members …

Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes

P Taylor, TT Talley, SB Hansen, RE Hibbs… - Biochemical …, 2007 - Elsevier
Neuronal nicotinic receptors, encoded by nine genes of the α and three of the β type of subunits,
and whose gene products assemble in distinct permutations as pentameric molecules, …

[HTML][HTML] Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein

SB Hansen, Z Radić, TT Talley, BE Molles… - Journal of Biological …, 2002 - ASBMB
The recent characterization of an acetylcholine binding protein (AChBP) from the fresh water
snail, Lymnaea stagnalis, shows it to be a structural homolog of the extracellular domain of …

Mapping the elusive neonicotinoid binding site

M Tomizawa, TT Talley, D Maltby… - Proceedings of the …, 2007 - National Acad Sciences
Two types of structurally similar nicotinic agonists have very different biological and
physicochemical properties. Neonicotinoids, important insecticides including imidacloprid and …

Atypical nicotinic agonist bound conformations conferring subtype selectivity

M Tomizawa, D Maltby, TT Talley… - Proceedings of the …, 2008 - National Acad Sciences
The nicotinic acetylcholine (ACh) receptor (nAChR) plays a crucial role in excitatory
neurotransmission and is an important target for drugs and insecticides. Diverse nAChR subtypes …