Background Chromatin remodeling, histone modifications and other chromatin-related processes
play a crucial role in gene regulation. A very useful technique to study these processes …

… Statistical significance was evaluated using Student t test or 1-way analysis of variance (ANOVA)
followed by Bonferroni correction for multiple comparisons (InStat 3.00; GraphPad …

… Relative gene expression was determined with the 2(−ΔΔC(T)) method. The housekeeping
gene glyceraldehyde-3-phosphate dehydrogenase was used to normalize gene expression …

… Don’t do more than needed since this might damage some of the cells. Avoid air bubbles. …
Analysis of the I/t plot clearly reveals that the drug effect develops very slowly, so that steady …

Several neonicotinoids have recently been shown to activate the nicotinic acetylcholine
receptor (nAChR) on human neurons. Moreover, imidacloprid (IMI) and other members of this …

Neonicotinoid pesticides, originally developed to target the insect nervous system, have
been reported to interact with human receptors and to activate rodent neurons. Therefore, we …

… A The volume of living MDCK-F cells (normalized with respect to the last control value at time
t=0 min) rises after the addition of the specific IK channel inhibitor charybdotoxin (CTX) and …

… & Takenaka, T. Effects of various potassium salts and proteases upon excitability of
intracellularly perfused squid giant axons. Proc Natl Acad Sci USA 52, 804–810, https://doi.org/…

Introduction hERG block potency is widely used to calculate a drug's safety margin against
its torsadogenic potential. Previous studies are confounded by use of different patch clamp …

In this review we focus on studies using atomic force microscopy (AFM) to describe the function
of nuclear pore complexes (NPC). After a short introduction of AFM we follow the route of …