Evidence for a prostate cancer susceptibility locus on the X chromosome.
…, D Stephan, E Gillanders, I Amundson, T Kainu… - Nature …, 1998 - nature.com
Over 200,000 new prostate cancer cases are diagnosed in the United States each year,
accounting for more than 35% of all cancer cases affecting men, and resulting in 40,000 deaths …
accounting for more than 35% of all cancer cases affecting men, and resulting in 40,000 deaths …
Population-based study of BRCA1 and BRCA2 mutations in 1035 unselected Finnish breast cancer patients
…, C Blomqvist, OP Kallioniemi, T Kainu… - Journal of the …, 2000 - academic.oup.com
Two highly penetrant genes involved in hereditary breast and/or ovarian cancer syndromes,
BRCA1 and BRCA2, have been identified (1, 2). Mutations in these genes occur throughout …
BRCA1 and BRCA2, have been identified (1, 2). Mutations in these genes occur throughout …
Somatic deletions in hereditary breast cancers implicate 13q21 as a putative novel breast cancer susceptibility locus
T Kainu, SHH Juo, R Desper… - Proceedings of the …, 2000 - National Acad Sciences
… models, in which each tree model T can be used to generate a distribution D(T) from which
one can sample tumors. By this, we mean that each sample from D(T) is a set of gains and …
one can sample tumors. By this, we mean that each sample from D(T) is a set of gains and …
A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes
…, DA Stephan, J Bailey-Wilson, SH Juo, T Kainu… - Human genetics, 2002 - Springer
Chromosomal region 13q21-q22 harbors a putative breast cancer susceptibility gene and
has been implicated as a common site for somatic deletions in a variety of malignant tumors. …
has been implicated as a common site for somatic deletions in a variety of malignant tumors. …
Low Proportion of BRCA1 and BRCA2 Mutations in Finnish Breast Cancer Families: Evidence for Additional Susceptibility Genes
…, B Ward, L Sarantaus, T Kainu… - Human molecular …, 1997 - academic.oup.com
… The exon 11 nt 4446 C→T substitution, the exon 12 splice acceptor mutation at nucleotide
−2 A→G and the exon 20 nt 5370 C→T substitution were identified each in one additional …
−2 A→G and the exon 20 nt 5370 C→T substitution were identified each in one additional …
Multiple founder effects and geographical clustering of BRCA1 and BRCA2 families in Finland
…, E Gillanders, K Syrjäkoski, T Kainu… - European Journal of …, 2000 - nature.com
… The variation of the age at diagnosis was analysed for both genes and both phenotypes by
unpaired t-test. Cumulative age-specific percentages of age at onset for breast and ovarian …
unpaired t-test. Cumulative age-specific percentages of age at onset for breast and ovarian …
Indian Agarwal megalencephalic leukodystrophy with cysts is caused by a common MLC1 mutation
JR Gorospe, BS Singhal, T Kainu, F Wu, D Stephan… - Neurology, 2004 - AAN Enterprises
Background: A distinct clinical syndrome characterized by megalencephaly, mild to moderate
cognitive decline, slowly progressive spasticity, ataxia, occasional seizures, and extensive …
cognitive decline, slowly progressive spasticity, ataxia, occasional seizures, and extensive …
A Genetic Epidemiological Study of Hereditary Prostate Cancer (HPC) in Finland: Frequent HPCX Linkage in Families with Late-onset Disease
…, J Smith, P Koivisto, A Baffoe-Bonnie, T Kainu… - Clinical cancer …, 2000 - AACR
Several predisposition loci for hereditary prostate cancer (HPC) have been suggested,
including HPC1 at 1q24-q25(OMIM #601518) and HPCX at Xq27-q28 (OMIM#300147). …
including HPC1 at 1q24-q25(OMIM #601518) and HPCX at Xq27-q28 (OMIM#300147). …
Localization of the peroxisome proliferator-activated receptor in the brain
T Kainu, AC Wikstrom, JA Gustafsson… - …, 1994 - journals.lww.com
THIS paper describes the localization of the a-type peroxisome proliferator-activated receptor
(PPARa) in the rat brain using immunocytochemistry and in situ hybridization. Expression …
(PPARa) in the rat brain using immunocytochemistry and in situ hybridization. Expression …
[PDF][PDF] Oncogenes and tumor suppressor genes in prostate cancer
W Isaacs, T Kainu - Epidemiologic reviews, 2001 - Citeseer
Our understanding of the genetic basis of human carcinogenesis while far from complete
has increased greatly over the past two decades. It is now clear that there exists multiple …
has increased greatly over the past two decades. It is now clear that there exists multiple …