Autophagy in infection, inflammation and immunity

V Deretic, T Saitoh, S Akira - Nature Reviews Immunology, 2013 - nature.com
… the polarization of T cells into T helper 17 (T H 17) cells. Autophagy also affects naive T
cell repertoire selection in the thymus and the survival and function of maturing T cells by …

Autophagy and autophagy-related proteins in the immune system

…, T Saitoh, H Nowag, C Münz, T Yoshimori - Nature …, 2015 - nature.com
… Ca 2+ mobilization after T cell stimulation 140 . This seems to affect not only effector T
cells but also regulatory T cells 141 . Moreover, CD4 + T cells defective in autophagy are …

Advances in Alzheimer's disease

R Katzman, T Saitoh - The FASEB journal, 1991 - Wiley Online Library
The problem of the etiology of Alzheimer's disease has not been solved. But in the past
several years there have been significant extensions of our knowledge of the disease and …

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

T Saitoh, N Fujita, MH Jang, S Uematsu, BG Yang… - Nature, 2008 - nature.com
… The results shown are mean ± sd Statistical significance was determined by the Student's
t-test. c, Typical distal colon appearance 6 days after the initiation of DSS administration. The …

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

K Matsunaga, T Saitoh, K Tabata, H Omori, T Satoh… - Nature cell …, 2009 - nature.com
Beclin 1, a protein essential for autophagy, binds to hVps34/Class III phosphatidylinositol-3-kinase
and UVRAG. Here, we have identified two Beclin 1 associated proteins, Atg14L and …

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

…, T Miyake, K Matsushita, T Okazaki, T Saitoh… - Nature …, 2010 - nature.com
… −/− splenic T cells differentiated into either type 1 or type 2 helper T cells (T H 1 and T H 2) …
Thus, we investigated the activation of T cells in the pulmonary lymph nodes 9 d after N. …

[PDF][PDF] Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1

T Saitoh, J Komano, Y Saitoh, T Misawa, M Takahama… - Cell host & …, 2012 - cell.com
… (F) CD4+ T cells were cocultured with neutrophils at the indicated T cell:neutrophil ratio.
The cells were incubated with an HIV-1 vector in the absence or presence of Dual-iODN. The …

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

…, DA Otero, J Kondo, Y Ihara, T Saitoh - Proceedings of the …, 1993 - National Acad Sciences
A neuropathological hallmark of Alzheimer disease (AD) is a widespread amyloid deposition.
We analyzed the entire amino acid sequences in an amyloid preparation and found, in …

The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

…, N Ge, L Flanagan, HAR De Silva, A Kittel, T Saitoh - Neuron, 1995 - cell.com
Non-Ap component of Alzheimefs disease amyloid (NAC) is the second component in the
amyloid from brain tissue of patients affected with Alzheimer's disease. Its precursor protein (…

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

T Saitoh, N Fujita, T Hayashi… - Proceedings of the …, 2009 - National Acad Sciences
Microbial nucleic acids are critical for the induction of innate immune responses, a host
defense mechanism against infection by microbes. Recent studies have indicated that double-…