The enzyme Na + ,K + -ATPase is a good model for receptor studies because of its known
functional correlates. The binding of digitalis to the enzyme observed in vitro satisfied the …

Cardiac Na + ,K + -ATPase, the receptor molecule for digitalis glycosides, have isoforms
with different intrinsic affinities for the glycosides. Expressionof these isoforms are under …

Large quantities of recombinant human aldose reductase were produced using Spodoptera
frugiperda cells and properties of the enzyme were characterized. Direct purification of the …

Tolerance to and physical dependence on several narcotic analgesics were demonstrated
in the rat. Daily doses of morphine at 30 and 120 mg kg and levorphanol at 6 and 15 mg kg …

The purpose of this study was to assess medication compliance and to document side effects
among a large number of Japanese patients receiving antihypertensive treatment. A total …

The in vitro sensitivity of cardiac (Na + + K + )-activated adenosine triphosphatase (ATPase)
activity [Mg ++ -dependent, (Na + + K + )-activated adenosine triphosphate (ATP) …

In 1957, Skou (73) demonstrated in crab nerves the presence of an ATPase activated by the
simultaneous presence of Na+ and K+. Skou wrote:" Charн acteristics of the system suggest …

In ligand binding studies, it is often difficult to apply kinetic analyses because of an uncertainty
in experimental data obtained at high ligand concentrations. Under such circumstances, K …

The complete amino acid sequence of human retina and muscle aldose reductase was
determined by nucleotide analysis of cDNA clones isolated using synthetic oligonucleotide …

Grayanotoxins are known to produce cardiac tachuyarrhythmias. It is unknown, however,
which of three mechanisms, ie, reentry, induction of automatic activity or induction of triggered …