User profiles for Takao Shimizu

Takao Shimizu

National Center for Global Health and Medicine
Verified email at ri.ncgm.go.jp
Cited by 63528

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

…, K Tobe, S Koyasu, K Taira, T Kitamura, T Shimizu… - Nature, 2003 - nature.com
Corrigendum (2004) Adiponectin (also known as 30-kDa adipocyte complement-related
protein; Acrp30) 1 , 2 , 3 , 4 is a hormone secreted by adipocytes that acts as an antidiabetic 5 , …

Cloning by functional expression of platelet-activating factor receptor from guinea-pig lung

…, H Okado, H Toh, K Ito, T Miyamoto, T Shimizu - Nature, 1991 - nature.com
PLATELET-activating factor (PAF), a unique phospholipid mediator, possesses potent
proinflammatory, smooth-muscle contractile and hypotensive activities, and appears to be crucial …

Prostaglandin F receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β

…, Y Taguchi, K Chin, M Mishima, T Shimizu… - Nature medicine, 2009 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by fibroblast
proliferation and excess deposition of collagen and other extracellular matrix (ECM) proteins, …

[HTML][HTML] A comprehensive classification system for lipids1

…, DW Russell, Y Seyama, W Shaw, T Shimizu… - Journal of lipid …, 2005 - ASBMB
Lipids are produced, transported, and recognized by the concerted actions of numerous
enzymes, binding proteins, and receptors. A comprehensive analysis of lipid molecules, "…

[HTML][HTML] Update of the LIPID MAPS comprehensive classification system for lipids1

…, RC Murphy, M Nishijima, CRH Raetz, T Shimizu… - Journal of lipid …, 2009 - ASBMB
In 2005, the International Lipid Classification and Nomenclature Committee under the
sponsorship of the LIPID MAPS Consortium developed and established a "Comprehensive …

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

T Yokomizo, T Izumi, K Chang, Y Takuwa, T Shimizu - Nature, 1997 - nature.com
Leukotriene B 4 (LTB 4 ) 1 is a potent chemoattractant that is primarily involved in inflammation,
immune responses and host defence against infection 2 . LTB 4 activates inflammatory …

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

…, K Ueki, Y Oike, S Ishii, K Hirose, T Shimizu… - Nature, 2010 - nature.com
Adiponectin is an anti-diabetic adipokine. Its receptors possess a seven-transmembrane
topology with the amino terminus located intracellularly, which is the opposite of G-protein-…

Role of cytosolic phospholipase A2 in allergic response and parturition

…, K Maki, K Ikuta, Y Ouchi, J Miyazaki, T Shimizu - Nature, 1997 - nature.com
Phospholipase A 2 (PLA 2 ) comprises a superfamily of enzymes that hydrolyse the ester
bond of phospholipids at the sn-2 position 1 , 2 , 3 . Among the members of this superfamily, …

A Second Leukotriene B4 Receptor, Blt2: A New Therapeutic Target in Inflammation and Immunological Disorders

…, K Kato, K Terawaki, T Izumi, T Shimizu - The Journal of …, 2000 - rupress.org
Leukotriene B 4 (LTB 4 ) is a potent chemoattractant and activator of both granulocytes and
macrophages. The actions of LTB 4 appear to be mediated by a specific G protein–coupled …

[HTML][HTML] Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family

K Noguchi, S Ishii, T Shimizu - Journal of Biological Chemistry, 2003 - ASBMB
Lysophosphatidic acid (LPA) is a bioactive lipid mediator with diverse physiological and
pathological actions on many types of cells. LPA has been widely considered to elicit its …