PPARs: therapeutic targets for metabolic disease
JP Berger, TE Akiyama, PT Meinke - Trends in pharmacological sciences, 2005 - cell.com
The three peroxisome-proliferator-activated receptor (PPAR) subtypes, PPAR-γ, PPAR-α and
PPAR-δ, are nuclear receptors that have been the focus of extensive research during the …
PPAR-δ, are nuclear receptors that have been the focus of extensive research during the …
PPARγ and PPARδ negatively regulate specific subsets of lipopolysaccharide and IFN-γ target genes in macrophages
Natural and synthetic agonists of the peroxisome proliferator-activated receptor γ (PPARγ)
regulate adipocyte differentiation, glucose homeostasis, and inflammatory responses. …
regulate adipocyte differentiation, glucose homeostasis, and inflammatory responses. …
Conditional disruption of the peroxisome proliferator-activated receptor γ gene in mice results in lowered expression of ABCA1, ABCG1, and apoE in macrophages …
TE Akiyama, S Sakai, G Lambert, CJ Nicol… - … and cellular biology, 2002 - Taylor & Francis
Disruption of the peroxisome proliferator-activated receptor γ (PPARγ) gene causes
embryonic lethality due to placental dysfunction. To circumvent this, a PPARγ conditional gene …
embryonic lethality due to placental dysfunction. To circumvent this, a PPARγ conditional gene …
Retinaldehyde represses adipogenesis and diet-induced obesity
O Ziouzenkova, G Orasanu, M Sharlach, TE Akiyama… - Nature medicine, 2007 - nature.com
The metabolism of vitamin A and the diverse effects of its metabolites are tightly controlled
by distinct retinoid-generating enzymes, retinoid-binding proteins and retinoid-activated …
by distinct retinoid-generating enzymes, retinoid-binding proteins and retinoid-activated …
A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice
DY Oh, E Walenta, TE Akiyama, WS Lagakos… - Nature medicine, 2014 - nature.com
It is well known that the ω–3 fatty acids (ω–3-FAs; also known as n–3 fatty acids) can exert
potent anti-inflammatory effects 1 , 2 , 3 , 4 . Commonly consumed as fish products, dietary …
potent anti-inflammatory effects 1 , 2 , 3 , 4 . Commonly consumed as fish products, dietary …
[HTML][HTML] Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells
…, J Pan, CJ Sinz, PE Carrington, TE Akiyama… - Molecular …, 2013 - Elsevier
The molecular mechanisms regulating secretion of the orexigenic-glucoregulatory hormone
ghrelin remain unclear. Based on qPCR analysis of FACS-purified gastric ghrelin cells, …
ghrelin remain unclear. Based on qPCR analysis of FACS-purified gastric ghrelin cells, …
[HTML][HTML] Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia [S]
…, A Petrov, M Wolff, X Tong, LC Wilsie, TE Akiyama… - Journal of lipid …, 2012 - ASBMB
In an attempt to understand the applicability of various animal models to dyslipidemia in
humans and to identify improved preclinical models for target discovery and validation for …
humans and to identify improved preclinical models for target discovery and validation for …
Diminished hepatocellular proliferation in mice humanized for the nuclear receptor peroxisome proliferator-activated receptor α
C Cheung, TE Akiyama, JM Ward, CJ Nicol… - Cancer research, 2004 - AACR
Lipid-lowering fibrate drugs function as agonists for the nuclear receptor peroxisome
proliferator-activated receptor α (PPARα). Sustained activation of PPARα leads to the development …
proliferator-activated receptor α (PPARα). Sustained activation of PPARα leads to the development …
Selective small-molecule agonists of G protein–coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice
…, S Lin, G Salituro, P Meinke, R Mosley, TE Akiyama… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE— Acute activation of G protein–coupled receptor 40 (GPR40) by free fatty acids
(FFAs) or synthetic GPR40 agonists enhances insulin secretion. However, it is still a matter …
(FFAs) or synthetic GPR40 agonists enhances insulin secretion. However, it is still a matter …
The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity
…, AM Yu, JM Ward, KW Krausz, TE Akiyama… - Drug metabolism and …, 2005 - ASPET
The cytochrome P450 (P450) CYP2E1 enzyme metabolizes and activates a wide array of
toxicological substrates, including alcohols, the widely used analgesic acetaminophen, …
toxicological substrates, including alcohols, the widely used analgesic acetaminophen, …