User profiles for Terrence R. Burke
Terrence R. Burke Jr.National Cancer Institute, National Institutes of Health Verified email at nih.gov Cited by 19604 |
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.
K Natarajan, S Singh, TR Burke Jr… - Proceedings of the …, 1996 - National Acad Sciences
Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives,
is known to have antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulatory …
is known to have antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulatory …
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
…, S Oishi, W Zhen, TR Burke Jr… - Proceedings of the …, 2006 - National Acad Sciences
Birt–Hogg–Dubé syndrome, a hamartoma disorder characterized by benign tumors of the
hair follicle, lung cysts, and renal neoplasia, is caused by germ-line mutations in the BHD(…
hair follicle, lung cysts, and renal neoplasia, is caused by germ-line mutations in the BHD(…
Coumarin-based inhibitors of HIV integrase
The structures of a large number of HIV-1 integrase inhibitors have in common two aryl units
separated by a central linker. Frequently at least one of these aryl moieties must contain 1,2-…
separated by a central linker. Frequently at least one of these aryl moieties must contain 1,2-…
Retroviral DNA integration: reaction pathway and critical intermediates
M Li, M Mizuuchi, TR Burke Jr, R Craigie - The EMBO journal, 2006 - embopress.org
The key DNA cutting and joining steps of retroviral DNA integration are carried out by the viral
integrase protein. Structures of the individual domains of integrase have been determined, …
integrase protein. Structures of the individual domains of integrase have been determined, …
Grb2 signaling in cell motility and cancer
Background: Metastasis is the primary cause of death in most human cancers, and
understanding the molecular mechanisms underpinning this multistep process is fundamental to …
understanding the molecular mechanisms underpinning this multistep process is fundamental to …
Structure activity of 3-aryl-1, 3-diketo-containing compounds as HIV-1 integrase inhibitors
The 4-aryl-2-hydroxy-4-oxo-2-butenoic acids and their isosteric tetrazoles are among an
emerging class of aryl β-diketo (ADK)-based agents which exhibit potent inhibition of HIV-1 …
emerging class of aryl β-diketo (ADK)-based agents which exhibit potent inhibition of HIV-1 …
Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation
Nuclear factor kappa-B (NF-κB) is a heterodimeric transcription factor with a pivotal role in
orchestrating immune and inflammatory processes. Inflammatory cytokines and prostanoids …
orchestrating immune and inflammatory processes. Inflammatory cytokines and prostanoids …
Chicoric acid analogues as HIV-1 integrase inhibitors
The present study was undertaken to examine structural features of l-chicoric acid (3) which
are important for potency against purified HIV-1 integrase and for reported cytoprotective …
are important for potency against purified HIV-1 integrase and for reported cytoprotective …
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1
…, JB McMahon, MC Nicklaus, TR Burke Jr… - Nature structural & …, 2009 - nature.com
Polo-like kinase-1 (Plk1) has a pivotal role in cell proliferation and is considered a potential
target for anticancer therapy. The noncatalytic polo-box domain (PBD) of Plk1 forms a …
target for anticancer therapy. The noncatalytic polo-box domain (PBD) of Plk1 forms a …
Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease
…, J Chen, GWA Milne, WG Rice, TR Burke… - Journal of medicinal …, 1996 - ACS Publications
The human immunodeficiency virus type one integrase (HIV-1 integrase) is required for
integration of a double-stranded DNA copy of the viral RNA genome into a host chromosome …
integration of a double-stranded DNA copy of the viral RNA genome into a host chromosome …