User profiles for Tezz Quon
 | Tezz QuonUniversity of Glasgow Verified email at glasgow.ac.uk Cited by 576 |
The trihelix family of transcription factors–light, stress and development
GT factors are the founding members of the trihelix transcription factor family. They bind GT
elements in light regulated genes, and their nature was uncovered in a burst of activity in the …
elements in light regulated genes, and their nature was uncovered in a burst of activity in the …
Therapeutic opportunities and challenges in targeting the orphan G protein-coupled receptor GPR35
GPR35 is a class A, rhodopsin-like G protein-coupled receptor (GPCR) first identified more
than 20 years ago. In the intervening period, identification of strong expression in the lower …
than 20 years ago. In the intervening period, identification of strong expression in the lower …
Combinatorial expression of GPCR isoforms affects signalling and drug responses
G-protein-coupled receptors (GPCRs) are membrane proteins that modulate physiology across
human tissues in response to extracellular signals. GPCR-mediated signalling can differ …
human tissues in response to extracellular signals. GPCR-mediated signalling can differ …
A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from class B crystal structures
…, C Koole, KJ Smith, JC Mobarec, J Simms, T Quon… - Molecular …, 2016 - ASPET
The glucagon-like peptide 1 (GLP-1) receptor is a class BG protein-coupled receptor (GPCR)
that is a key target for treatments for type II diabetes and obesity. This receptor, like other …
that is a key target for treatments for type II diabetes and obesity. This receptor, like other …
PETAL LOSS, a trihelix transcription factor that represses growth in Arabidopsis thaliana, binds the energy-sensing SnRK1 kinase AKIN10
M O'Brien, RN Kaplan-Levy, T Quon… - Journal of …, 2015 - academic.oup.com
Organogenesis in plants involves differential growth. Rapidly growing primordia are distinguished
from the meristem and each other by slower growing boundaries. PETAL LOSS (PTL) …
from the meristem and each other by slower growing boundaries. PETAL LOSS (PTL) …
G protein-coupled receptor GPR35 suppresses lipid accumulation in hepatocytes
LC Lin, T Quon, S Engberg, AE Mackenzie… - ACS Pharmacology & …, 2021 - ACS Publications
Although prevalent, nonalcoholic fatty liver disease is not currently treated effectively with
medicines. Initially, using wild-type and genome-edited clones of the human hepatocyte cell …
medicines. Initially, using wild-type and genome-edited clones of the human hepatocyte cell …
[HTML][HTML] Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation
Despite recent advances in structural definition of GPCR–G protein complexes, the basis of
receptor selectivity between G proteins remains unclear. The Gα 12 and Gα 13 subtypes …
receptor selectivity between G proteins remains unclear. The Gα 12 and Gα 13 subtypes …
[HTML][HTML] PETAL LOSS and ROXY1 Interact to Limit Growth Within and between Sepals But to Promote Petal Initiation in Arabidopsis thaliana
The activity of genes controlling organ development may be associated with the redox state
of subregions within the meristem. Glutaredoxins react to the level of oxidative potential and …
of subregions within the meristem. Glutaredoxins react to the level of oxidative potential and …
Functional domains of the PETAL LOSS protein, a trihelix transcription factor that represses regional growth in Arabidopsis thaliana
RN Kaplan‐Levy, T Quon, M O'Brien… - The Plant …, 2014 - Wiley Online Library
PETAL LOSS ( PTL ) is a trihelix transcription factor that represses growth, especially between
sepal primordia. As one of 30 trihelix proteins in A rabidopsis, it falls in the GT 2 clade with …
sepal primordia. As one of 30 trihelix proteins in A rabidopsis, it falls in the GT 2 clade with …
[HTML][HTML] G protein–receptor kinases 5/6 are the key regulators of G protein–coupled receptor 35–arrestin interactions
Human G protein–coupled receptor 35 is regulated by agonist-mediated phosphorylation of
a set of five phospho-acceptor amino acids within its C-terminal tail. Alteration of both Ser …
a set of five phospho-acceptor amino acids within its C-terminal tail. Alteration of both Ser …