Tinnitus has been associated with increased spontaneous and evoked activity, increased
neural synchrony, and reorganization of tonotopic maps of auditory nuclei. However, the …

Nearly sixty years ago Fredrich Timm developed a histochemical technique that revealed a
rich reserve of free zinc in distinct regions of the brain. Subsequent electron microscopy …

In the dorsal cochlear nucleus, long-term synaptic plasticity can be induced at the parallel
fiber inputs that synapse onto both fusiform principal neurons and cartwheel feedforward …

Tinnitus is a pervasive public health issue that affects ∼15% of the United States population.
Similar estimates have also been shown on a global scale, with similar prevalence found in …

10.7554/eLife.07242.001 Vulnerability to noise-induced tinnitus is associated with increased
spontaneous firing rate in dorsal cochlear nucleus principal neurons, fusiform cells. This …

Damage to sensory organs triggers compensatory plasticity mechanisms in sensory cortices.
These plasticity mechanisms result in restored cortical responses, despite reduced …

Repetitive activation of excitatory synapses in the central nervous system results in a long-lasting
increase in synaptic transmission called long-term potentiation (LTP). It is generally …

Activity-dependent changes in neuronal excitability and synaptic strength are thought to
underlie memory encoding. In hippocampal CA1 neurons, small conductance Ca 2+ -activated …

Synapses may undergo long-term increases or decreases in synaptic strength dependent
on critical differences in the timing between pre-and postsynaptic activity. Such spike-timing-…

Mechanisms of plasticity have traditionally been ascribed to higher-order sensory processing
areas such as the cortex, whereas early sensory processing centers have been considered …