[HTML][HTML] A review of Gaucher disease pathophysiology, clinical presentation and treatments
…, C Serratrice, R Froissart, C Caillaud, T Levade… - International journal of …, 2017 - mdpi.com
Gaucher disease (GD, ORPHA355) is a rare, autosomal recessive genetic disorder. It is
caused by a deficiency of the lysosomal enzyme, glucocerebrosidase, which leads to an …
caused by a deficiency of the lysosomal enzyme, glucocerebrosidase, which leads to an …
Ceramide in apoptosis signaling: relationship with oxidative stress
…, V Gouazé, R Salvayre, T Levade - Free Radical Biology and …, 2001 - Elsevier
Ceramide is one of the major sphingosine-based lipid second messengers that is generated
in response to various extracellular agents. However, while widespread attention has …
in response to various extracellular agents. However, while widespread attention has …
[HTML][HTML] The TNF paradox in cancer progression and immunotherapy
A Montfort, C Colacios, T Levade… - Frontiers in …, 2019 - frontiersin.org
Tumor necrosis factor alpha (TNF)-dependent modulation of immune responses and cell
death processes has long been the subject of intense research. Yet, its role in cancer …
death processes has long been the subject of intense research. Yet, its role in cancer …
Daunorubicin‐induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.
JP Jaffrezou, T Levade, A Bettaieb, N Andrieu… - The EMBO …, 1996 - embopress.org
The nature of the signaling pathway(s) which initiate drug‐triggered apoptosis remains
largely unknown and is of fundamental importance in understanding cell death induced by …
largely unknown and is of fundamental importance in understanding cell death induced by …
[HTML][HTML] Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-α-induced cell death
B Liu, N Andrieu-Abadie, T Levade, P Zhang… - Journal of Biological …, 1998 - ASBMB
Tumor necrosis factor-α (TNFα)-induced cell death involves a diverse array of mediators and
regulators including proteases, reactive oxygen species, the sphingolipid ceramide, and Bcl…
regulators including proteases, reactive oxygen species, the sphingolipid ceramide, and Bcl…
[HTML][HTML] TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma
…, P Rochaix, N Andrieu-Abadie, T Levade… - Nature …, 2017 - nature.com
Antibodies against programmed cell death-1 (PD-1) have considerably changed the treatment
for melanoma. However, many patients do not display therapeutic response or eventually …
for melanoma. However, many patients do not display therapeutic response or eventually …
[HTML][HTML] Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy
S Pattingre, C Bauvy, S Carpentier, T Levade… - Journal of Biological …, 2009 - ASBMB
Macroautophagy is a vacuolar lysosomal catabolic pathway that is stimulated during
periods of nutrient starvation to preserve cell integrity. Ceramide is a bioactive sphingolipid …
periods of nutrient starvation to preserve cell integrity. Ceramide is a bioactive sphingolipid …
Recommendations on the diagnosis and management of Niemann-Pick disease type C
…, B Bembi, A Covanis, T Levade… - Molecular genetics and …, 2009 - Elsevier
Niemann-Pick disease type C (NP-C) is a lysosomal storage disease in which impaired
intracellular lipid trafficking leads to excess storage of cholesterol and glycosphingolipids in the …
intracellular lipid trafficking leads to excess storage of cholesterol and glycosphingolipids in the …
[HTML][HTML] Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
…, F Scarlatti, G Sala, S Carpentier, T Levade… - Journal of Biological …, 2006 - ASBMB
The sphingolipid ceramide induces macroautophagy (here called autophagy) and cell death
with autophagic features in cancer cells. Here we show that overexpression of sphingosine …
with autophagic features in cancer cells. Here we show that overexpression of sphingosine …
Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice
…, C Rancoule, K Kuba, M Ruiz-Gayo, T Levade… - Diabetes, 2012 - Am Diabetes Assoc
Both acute and chronic apelin treatment have been shown to improve insulin sensitivity in
mice. However, the effects of apelin on fatty acid oxidation (FAO) during obesity-related insulin …
mice. However, the effects of apelin on fatty acid oxidation (FAO) during obesity-related insulin …