User profiles for Thomas R. Sutter

Thomas R Sutter

Professor and Feinstone Chair of Excellence in Molecular Biology University of Memphis
Verified email at memphis.edu
Cited by 12547

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1

…, S Amin, SS Hecht, FP Guengerich, TR Sutter - Cancer research, 1996 - AACR
A human cytochrome P-450 (P450) 1B1 cDNA was expressed in Saccharomyces cerevisiae,
and the microsomes containing P450 1B1 were used to examine the selectivity of this …

17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.

…, JQ Cao, NJ Walker, TR Sutter - Proceedings of the …, 1996 - National Acad Sciences
The 4-hydroxy metabolite of 17 beta-estradiol (E2) has been implicated in the carcinogenicity
of this hormone. Previous studies showed that aryl hydrocarbon-receptor agonists induced …

Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

TR Sutter, YM Tang, CL Hayes, YYP Wo… - Journal of Biological …, 1994 - Elsevier
Previously, levels of a novel human mRNA, detected by a recombinant cDNA designated
clone 1, were shown to be increased 50-fold in response to treatment of a keratinocyte cell line …

[HTML][HTML] Role of Transcription Factor Nrf2 in the Induction of Hepatic Phase 2 and Antioxidative Enzymes in vivo by the Cancer Chemoprotective Agent, 3H-1, 2 …

MK Kwak, K Itoh, M Yamamoto, TR Sutter… - Molecular Medicine, 2001 - Springer
Background The induction of phase 2 enzymes by dithiolethiones such as oltipraz is an
effective means for achieving protection against environmental carcinogens in animals and …

Metabolism of benzo [a] pyrene and benzo [a] pyrene-7, 8-diol by human cytochrome P450 1B1.

…, NJ Walker, MA Trush, PT Strickland, TR Sutter - …, 1998 - academic.oup.com
Benzo[a]pyrene (B[a]P), a ubiquitous environmental, tobacco and dietary carcinogen, has
been implicated in human cancer etiology. The role of human cytochrome P450 1B1 in the …

Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice

…, CR Williams, KT Liby, MB Sporn, TR Sutter… - …, 2009 - academic.oup.com
Loss of NF-E2-related factor 2 (Nrf2) signaling increases susceptibility to acute toxicity,
inflammation and carcinogenesis in mice due to the inability to mount adaptive responses. In …

Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells.

…, BT Pentecost, MJ Fasco, Y Li, TR Sutter - …, 1998 - academic.oup.com
Human cytochromes P450 1A1 (CYP1A1) and P450 1B1 (CYP1B1) catalyze the metabolic
activation of a number of procarcinogens and the hydroxylation of 17beta-estradiol (E2) at …

Chapter 5: Tissue-specific synthesis and oxidative metabolism of estrogens

CR Jefcoate, JG Liehr, RJ Santen, TR Sutter… - JNCI …, 2000 - academic.oup.com
Estrogen exposure represents the major known risk factor for development of breast cancer
in women and is implicated in the development of prostate cancer in men. Human breast …

Catalytic properties of polymorphic human cytochrome P450 1B1 variants

T Shimada, J Watanabe, K Kawajiri, TR Sutter… - …, 1999 - academic.oup.com
Four polymorphic human cytochrome P450 (CYP) 1B1 allelic variants, namely Arg48,Ala119,Leu432,Asn453,
Arg48,Ser119,Leu432,Asn453, Arg48,Ala119,Val432,Asn-453 and Arg48,…

[HTML][HTML] Isolation and characterization of the human cytochrome P450 CYP1B1 gene

…, J Stewart, AL Hawkins, CA Griffin, TR Sutter… - Journal of Biological …, 1996 - ASBMB
Previously, we identified a novel human cytochrome P450 cDNA that is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) and represents the first member of a new subfamily …