User profiles for Thomas R. Sutter
Thomas R SutterProfessor and Feinstone Chair of Excellence in Molecular Biology University of Memphis Verified email at memphis.edu Cited by 12547 |
Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1
…, S Amin, SS Hecht, FP Guengerich, TR Sutter - Cancer research, 1996 - AACR
A human cytochrome P-450 (P450) 1B1 cDNA was expressed in Saccharomyces cerevisiae,
and the microsomes containing P450 1B1 were used to examine the selectivity of this …
and the microsomes containing P450 1B1 were used to examine the selectivity of this …
17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.
The 4-hydroxy metabolite of 17 beta-estradiol (E2) has been implicated in the carcinogenicity
of this hormone. Previous studies showed that aryl hydrocarbon-receptor agonists induced …
of this hormone. Previous studies showed that aryl hydrocarbon-receptor agonists induced …
Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.
TR Sutter, YM Tang, CL Hayes, YYP Wo… - Journal of Biological …, 1994 - Elsevier
Previously, levels of a novel human mRNA, detected by a recombinant cDNA designated
clone 1, were shown to be increased 50-fold in response to treatment of a keratinocyte cell line …
clone 1, were shown to be increased 50-fold in response to treatment of a keratinocyte cell line …
[HTML][HTML] Role of Transcription Factor Nrf2 in the Induction of Hepatic Phase 2 and Antioxidative Enzymes in vivo by the Cancer Chemoprotective Agent, 3H-1, 2 …
MK Kwak, K Itoh, M Yamamoto, TR Sutter… - Molecular Medicine, 2001 - Springer
Background The induction of phase 2 enzymes by dithiolethiones such as oltipraz is an
effective means for achieving protection against environmental carcinogens in animals and …
effective means for achieving protection against environmental carcinogens in animals and …
Metabolism of benzo [a] pyrene and benzo [a] pyrene-7, 8-diol by human cytochrome P450 1B1.
Benzo[a]pyrene (B[a]P), a ubiquitous environmental, tobacco and dietary carcinogen, has
been implicated in human cancer etiology. The role of human cytochrome P450 1B1 in the …
been implicated in human cancer etiology. The role of human cytochrome P450 1B1 in the …
Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice
…, CR Williams, KT Liby, MB Sporn, TR Sutter… - …, 2009 - academic.oup.com
Loss of NF-E2-related factor 2 (Nrf2) signaling increases susceptibility to acute toxicity,
inflammation and carcinogenesis in mice due to the inability to mount adaptive responses. In …
inflammation and carcinogenesis in mice due to the inability to mount adaptive responses. In …
Differential expression of CYP1A1 and CYP1B1 in human breast epithelial cells and breast tumor cells.
Human cytochromes P450 1A1 (CYP1A1) and P450 1B1 (CYP1B1) catalyze the metabolic
activation of a number of procarcinogens and the hydroxylation of 17beta-estradiol (E2) at …
activation of a number of procarcinogens and the hydroxylation of 17beta-estradiol (E2) at …
Chapter 5: Tissue-specific synthesis and oxidative metabolism of estrogens
Estrogen exposure represents the major known risk factor for development of breast cancer
in women and is implicated in the development of prostate cancer in men. Human breast …
in women and is implicated in the development of prostate cancer in men. Human breast …
Catalytic properties of polymorphic human cytochrome P450 1B1 variants
T Shimada, J Watanabe, K Kawajiri, TR Sutter… - …, 1999 - academic.oup.com
Four polymorphic human cytochrome P450 (CYP) 1B1 allelic variants, namely Arg48,Ala119,Leu432,Asn453,
Arg48,Ser119,Leu432,Asn453, Arg48,Ala119,Val432,Asn-453 and Arg48,…
Arg48,Ser119,Leu432,Asn453, Arg48,Ala119,Val432,Asn-453 and Arg48,…
[HTML][HTML] Isolation and characterization of the human cytochrome P450 CYP1B1 gene
…, J Stewart, AL Hawkins, CA Griffin, TR Sutter… - Journal of Biological …, 1996 - ASBMB
Previously, we identified a novel human cytochrome P450 cDNA that is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD) and represents the first member of a new subfamily …
(TCDD) and represents the first member of a new subfamily …