Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor
…, LF Nelms, SG Des Etages, LS Hayes, TT Kawabata… - Science, 2003 - science.org
Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an
excellent target for clinical immunosuppression. We report the development of a specific, …
excellent target for clinical immunosuppression. We report the development of a specific, …
[PDF][PDF] The mechanism of action of tofacitinib-an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis
JA Hodge, TT Kawabata, S Krishnaswami… - Clin Exp …, 2016 - clinexprheumatol.org
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterised by
infiltration of immune cells into the affected synovium, release of inflammatory cytokines and …
infiltration of immune cells into the affected synovium, release of inflammatory cytokines and …
Immunological responses to exogenous insulin
SE Fineberg, TT Kawabata, D Finco-Kent… - Endocrine …, 2007 - academic.oup.com
Regardless of purity and origin, therapeutic insulins continue to be immunogenic in humans.
However, severe immunological complications occur rarely, and less severe events affect a …
However, severe immunological complications occur rarely, and less severe events affect a …
Mechanisms of in vitro immunosuppression by hepatocyte-generated cyclophosphamide metabolites and 4-hydroperoxycyclophosphamide
TT Kawabata, MY Chapman, K Dong-Hyun… - Biochemical …, 1990 - Elsevier
Cyclophosphamide (CY) is metabolized to 4-hydroxy-CY which spontaneously breaks down
to the reactive intermediates, phosphoramide mustard (PAM) and acrolein. The alkylating …
to the reactive intermediates, phosphoramide mustard (PAM) and acrolein. The alkylating …
Assessing the potential to induce respiratory hypersensitivity
MP Holsapple, D Jones, TT Kawabata… - Toxicological …, 2006 - academic.oup.com
Acute and repeat dose inhalation studies have been an important part of the safety assessment
of drugs, chemicals, and other products throughout the world for many years. It is known …
of drugs, chemicals, and other products throughout the world for many years. It is known …
Suppression of the in Vitro Humoral Immune Response of Mouse Splenocytes by Benzo(a)pyrene Metabolites and Inhibition of Benzo(a)pyrene-induced …
TT Kawabata, KL White Jr - Cancer research, 1987 - AACR
Several investigators have demonstrated that the humoral immune response of mice and
splenocyte cultures was suppressed with benzo(a)pyrene [B(a)P] exposure. The mechanism of …
splenocyte cultures was suppressed with benzo(a)pyrene [B(a)P] exposure. The mechanism of …
Suppression of the in vitro humoral immune response of mouse splenocytes by 7, 12-dimethylbenz [a] anthracene metabolites and inhibition of immunosuppression …
GS Ladics, TT Kawabata, KL White Jr - Toxicology and applied …, 1991 - Elsevier
Exposure to 7,12-dimethylbenz[a]anthracene (DMBA) has been demonstrated by numerous
investigators to result in suppression of both humoral and cell-mediated immune responses …
investigators to result in suppression of both humoral and cell-mediated immune responses …
Specific antibody responses to subtilisin Carlsberg (Alcalase) in mice: development of an intranasal exposure model
…, LS Babcock, PA Horn, TT Kawabata - Fundamental and Applied …, 1996 - Elsevier
An intranasal (in) dosing model was developed in mice as a potential alternative to more
difficult, time-consuming, and costly guinea pig intratracheal (GPIT) or mouse intratracheal …
difficult, time-consuming, and costly guinea pig intratracheal (GPIT) or mouse intratracheal …
Developmental immunotoxicity (DIT) testing of pharmaceuticals: current practices, state of the science, knowledge gaps, and recommendations
…, GJ Chellman, TT Kawabata… - Journal of …, 2012 - Taylor & Francis
The development and regulatory approval of immunomodulatory pharmaceuticals to treat
many human diseases has increased significantly over the last two decades. As discussed by …
many human diseases has increased significantly over the last two decades. As discussed by …
Covalent binding of the nitroso metabolite of sulfamethoxazole is important in induction of drug-specific T-cell responses in vivo
…, DR Petersen, JA Ware, JR Piccotti, TT Kawabata… - Molecular …, 2008 - ASPET
Immune-mediated drug hypersensitivity reactions (IDHRs) represent a significant problem
due to their unpredictable and severe nature, as well as the lack of understanding of the …
due to their unpredictable and severe nature, as well as the lack of understanding of the …