To clarify the physiological role of Na + -d-glucose cotransporter SGLT1 in small intestine and
kidney, Sglt1 −/− mice were generated and characterized phenotypically. After gavage of d…

Tubuloglomerular feedback (TGF) stabilizes nephron function from minute to minute and
adapts to different steady-state inputs to maintain this capability. Such adaptation inherently …

Mutations in the gene encoding for the Na+-glucose co-transporter SGLT2 (SLC5A2)
associate with familial renal glucosuria, but the role of SGLT2 in the kidney is incompletely …

Sodium–glucose cotransporters SGLT1 (encoded by SGLT1, also known as SLC5A1) and
SGLT2 (encoded by SGLT2, also known as SLC5A2) are important mediators of epithelial …

Aldosterone plays a major role in the regulation of salt balance and the pathophysiology of
cardiovascular and renal diseases. Many aldosterone-regulated genes — including that …

Activation of the glucagon-like peptide (GLP)-1 receptor (GLP-1R) and inhibition of dipeptidyl
peptidase-4 (DPP-4) are new antidiabetic strategies. The GLP-1R and DPP-4 are also …

Tubular secretion of the organic cation, creatinine, limits its value as a marker of glomerular
filtration rate (GFR) but the molecular determinants of this pathway are unclear. The organic …

Our previous work has shown that gene knockout of the sodium-glucose cotransporter SGLT2
modestly lowered blood glucose in streptozotocin-diabetic mice (BG; from 470 to 300 mg/…

The Na-glucose cotransporter SGLT2 mediates high-capacity glucose uptake in the early
proximal tubule and SGLT2 inhibitors are developed as new antidiabetic drugs. We used gene-…

Objectives : We hypothesized that cardiac myocyte-specific overexpression of caveolin-3 (Cav-3),
a muscle-specific caveolin, would alter natriuretic peptide signaling and attenuate …