Gap junctions and connexin hemichannels mediate intercellular and extracellular
communication, respectively. While gap junctions are seen as the “good guys” by controlling …

The family of G protein-coupled receptors (GPCRs) is the largest class of membrane proteins
and an important drug target due to their role in many (patho)physiological processes. …

G protein-coupled receptors (GPCRs), belonging to the largest class of membrane proteins,
play a prominent role in many (patho)physiological processes and are, therefore, important …

Photodynamic therapy (PDT) eradicates tumors by the local activation of a photosensitizer
with near-infrared light. One of the aspects hampering the clinical use of PDT is the poor …

Glioblastoma (GBM) is the most aggressive and an incurable type of brain cancer. Human
cytomegalovirus (HCMV) DNA and encoded proteins, including the chemokine receptor US28…

While various GPCRs, including US28, display constitutive, ligand-independent activity, it
remains to be established whether ligand-dependent and -independent active conformations …

Cancer is a heterogeneous disease, requiring treatment tailored to the unique phenotype of
the patient's tumor. Monoclonal antibodies (mAbs) and variants thereof have enabled …

mAbs have been instrumental for targeted cancer therapies. However, their relatively large
size and physicochemical properties result in a heterogenous distribution in the tumor …

Introduction Monoclonal antibodies have revolutionized personalized medicine for cancer in
recent decades. Despite their broad application in oncology, their large size and complexity …

Herpesviruses are ubiquitous pathogens that establish lifelong, latent infections in their host.
Spontaneous reactivation of herpesviruses is often asymptomatic or clinically manageable …