Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6
…, AP Evan, VM Rajendran, H Velazquez, TP Nottoli… - Nature …, 2006 - nature.com
Urolithiasis is one of the most common urologic diseases in industrialized societies. Calcium
oxalate is the predominant component in 70–80% of kidney stones 1 , and small changes …
oxalate is the predominant component in 70–80% of kidney stones 1 , and small changes …
Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter
…, RL Stephens, ER Hill, T Nottoli… - Proceedings of the …, 2006 - National Acad Sciences
There are three known high-affinity targets for cocaine: the dopamine transporter (DAT), the
serotonin transporter (SERT), and the norepinephrine transporter (NET). Decades of studies …
serotonin transporter (SERT), and the norepinephrine transporter (NET). Decades of studies …
Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage
In nonneuronopathic type 1 Gaucher disease (GD1), mutations in the glucocerebrosidase
gene (GBA1) gene result in glucocerebrosidase deficiency and the accumulation of its …
gene (GBA1) gene result in glucocerebrosidase deficiency and the accumulation of its …
Transcription factor AP-2γ is essential in the extra-embryonic lineages for early postimplantation development
HJ Auman, T Nottoli, O Lakiza, Q Winger, S Donaldson… - 2002 - journals.biologists.com
The members of the AP-2 family of transcription factors play important roles during mammalian
development and morphogenesis. AP-2γ (Tcfap2c – Mouse Genome Informatics) is a …
development and morphogenesis. AP-2γ (Tcfap2c – Mouse Genome Informatics) is a …
The HPV16 E5 protein: expression, detection, and stable complex formation with transmembrane proteins in COS cells
ES Hwang, T Nottoli, D Dimaio - Virology, 1995 - Elsevier
The human papillomavirus-16 (HPV16) E5 gene is able to induce stable growth transformation
and transient mitogenic stimulation in a variety of cultured cell systems. To characterize …
and transient mitogenic stimulation in a variety of cultured cell systems. To characterize …
AP-2-null cells disrupt morphogenesis of the eye, face, and limbs in chimeric mice
T Nottoli, S Hagopian-Donaldson… - Proceedings of the …, 1998 - National Acad Sciences
The homozygous disruption of the mouse AP-2 gene yields a complex and lethal phenotype
that results from defective development of the neural tube, head, and body wall. The severe …
that results from defective development of the neural tube, head, and body wall. The severe …
AP-2αTranscription factor is required for early morphogenesis of the lens vesicle
JA West-Mays, J Zhang, T Nottoli… - Developmental …, 1999 - Elsevier
AP-2transcription factors are a family of retinoic acid-responsive genes, which are involved
in complex morphogenetic processes. In the current study, we determine the requirement …
in complex morphogenetic processes. In the current study, we determine the requirement …
[PDF][PDF] Impaired LRP6-TCF7L2 activity enhances smooth muscle cell plasticity and causes coronary artery disease
R Srivastava, J Zhang, G Go, A Narayanan, TP Nottoli… - Cell reports, 2015 - cell.com
Mutations in Wnt-signaling coreceptor LRP6 have been linked to coronary artery disease (CAD)
by unknown mechanisms. Here, we show that reduced LRP6 activity in LRP6 R611C …
by unknown mechanisms. Here, we show that reduced LRP6 activity in LRP6 R611C …
Disruption of cAMP and prostaglandin E2 transport by multidrug resistance protein 4 deficiency alters cAMP-mediated signaling and nociceptive response
ZP Lin, YL Zhu, DR Johnson, KP Rice, T Nottoli… - Molecular …, 2008 - ASPET
Multidrug resistance protein 4 (MRP4; ABCC4) is a member of the MRP/ATP-binding cassette
family serving as a transmembrane transporter involved in energy-dependent efflux of …
family serving as a transmembrane transporter involved in energy-dependent efflux of …
Specific disruption of Abca1 targeting largely mimics the effects of miR-33 knockout on macrophage cholesterol efflux and atherosclerotic plaque development
…, X Zhang, A Canfrán-Duque, T Nottoli… - Circulation …, 2019 - Am Heart Assoc
Rationale: Inhibition of miR-33 reduces atherosclerotic plaque burden, but miR-33 deficient
mice are predisposed to the development of obesity and metabolic dysfunction. The …
mice are predisposed to the development of obesity and metabolic dysfunction. The …