Estrogen receptor-positive (ER + ) breast cancers frequently remain dependent on ER
signaling even after acquiring resistance to endocrine agents, prompting the development of …

Several recent studies show that inhibition of the hepatic transport proteins organic anion-transporting
polypeptide 1B1 (OATP1B1) and 1B3 (OATP1B3) can result in clinically relevant …

Introduction: The sandwich-cultured hepatocyte (SCH) model has become an invaluable in
vitro tool for studying hepatic drug transport, metabolism, biliary excretion and toxicity. The …

Multiple myeloma (MM) arises from malignant immunoglobulin (Ig)-secreting plasma cells
and remains an incurable, often lethal disease despite therapeutic advances. The unfolded-…

… Tom De Bruyn (Tom De Bruyn is a geographer and development planner. He is currently …
Tom De Bruyn has prepared this article on the occasion of BASUG’s forum on “Remittances …

Introduction The selective estrogen receptor degrader (SERD) and full receptor antagonist
provides an important therapeutic option for hormone receptor (HR)-positive breast cancer. …

Development co-operation has traditionally been the playing field of governments, multilateral
institutions, and established development NGOs. In the past decade, however, other …

… a single pool of human hepatocytes measured in this study or previously by De Bruyn et al.
… Tom De Bruyn received a PhD scholarship from the Agency for Innovation by Science and …

This work explores the utility of the cynomolgus monkey as a preclinical model to predict
hepatic uptake clearance mediated by organic anion transporting polypeptide (OATP) …

Food can have a significant impact on the pharmacokinetics of orally administered drugs, as
it may affect drug solubility as well as permeability. Since fed state conditions cannot easily …