Ethnic differences in genetic polymorphisms in UDP-glucuronosyltransferase 1A1 (UGT1A1)
were investigated among African-Americans, Caucasians, and Japanese using samples …

Cytochrome P450 (P450) 2B6 is a hepatic enzyme of potential importance for the metabolism
of clinically used drugs and environmental or abused toxicants. Genetic polymorphisms …

Various plasticizers and flame retardants are contained in building materials and furniture
produced for indoor environments. However, some of these material inclusions have been …

Glutathione-S-transferase class Omega (GSTO 1-1) belongs to a new subfamily of GSTs,
which is identical with human monomethylarsonic acid (MMA(V)) reductase, the rate limiting …

… Hideto Jinno, Toshiko Tanaka-Kagawa, Nobumitsu Hanioka, Mayumi Saeki, Seiichi
Ishida, Tetsuji Nishimura, Masanori Ando, Yoshiro Saito, Shogo Ozawa and Jun-ichi Sawada …

Quinones are reactive chemical species that cause cellular damage by modifying protein
thiols and/or catalyzing the reduction of oxygen to reactive oxygen species, thereby promoting …

SN-38 (7-ethyl-10-hydroxycamptothecin), an active metabolite of the antitumor prodrug
irinotecan, is conjugated and detoxified to SN-38 10-O-β-d-glucuronide by hepatic UDP-…

Individuals living in general indoor environments are exposed to a greater variety of chemical
pollutants, albeit at lower concentrations, compared with industrial workers in occupational …

Human constitutive androstane (or active) receptor (hCAR), a member of the nuclear receptor
superfamily NR1I3, regulates the expression of several genes that are mainly involved in …

A variety of chemicals have been used in a wide range of indoor materials, such as wallpaper
and furniture, and some of them are released into the indoor air. The level of consumption …