The nonsteroidal antiinflammatory drug diclofenac causes rare but significant cases of serious
hepatotoxicity, typically with a delayed onset (>1–3 months). Because there is no simple …

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with idiosyncratic
hepatotoxicity in susceptible patients. The molecular mechanisms underlying this toxicity have …

Idiosyncratic drug-induced liver injury (DILI) is a major clinical problem and poses a
considerable challenge for drug development as an increasing number of successfully launched …

Reductionism to cellular and molecular mechanisms is one of the cornerstones of modern
toxicology, forming the basis for a better understanding of individual toxic effects, and …

Small intestinal mucosal injury is a frequent adverse effect caused by nonsteroidal anti-inflammatory
drugs (NSAIDs). The underlying mechanisms are not completely understood, but …

In a few patients diclofenac produces mild increases in serum aminotransferase activity and
in rare cases may be associated with the occurrence of fulminant hepatic necrosis. Both …

Certain drugs containing a nitroaromatic moiety (eg, tolcapone, nimesulide, nilutamide,
flutamide, nitrofurantoin) have been associated with organ-selective toxicity including rare cases …

We have previously demonstrated that a small molecule inhibitor of bacterial β-glucuronidase
(Inh-1; [1-((6,8-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)-3-(4-ethoxyphenyl)-1-(2-…

Background/Aims: Peroxisome proliferator-activated receptor-γ, which is involved in the
regulation of lipid homeostasis, is upregulated in the liver of obese and diabetic mice, but the …

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that is safe at
therapeutic doses but which can precipitate liver injury at high doses. We have previously found …