Publisher Summary This chapter reviews recent advances in the chemistry and biochemistry
of C-nucleosides, the literature concerning C-arylglycoside (ie, nonnitrogen heterocyclic C-…

Parkinson’s disease psychosis (PDP) is a condition that may develop in up to 60 % of
Parkinson’s patients, and is a major reason for nursing home placement for those affected. There …

8-Methoxy-2-(di-n-propylamino) tetralin (8-OMe-DPAT) and 8-hydroxy-2-(di-n-propylamino)
tetralin (8-OH-DPAT) are two new drugs exerting selective actions on brain 5-HT …

Rationale Clozapine is a unique antipsychotic, with efficacy against positive symptoms in
treatment-resistant schizophrenic patients, and the ability to improve cognition and treat the …

We have used a cell-based functional assay to define the pharmacological profiles of a wide
range of central nervous system active compounds as agonists, competitive antagonists, …

We are currently investigating thepharmacological properties of 2-aminotetralins and related
compounds using biochemical and behavioral methods recently pub-lished. 1, 2 It has …

Drugs that antagonize D 2 -like receptors are effective antipsychotics, but the debilitating
movement disorder side effects associated with these drugs cannot be dissociated from …

Three series of heterocyclic dipeptidomimetics have been synthesized. The compounds
were designed as amino acid-glycine mimetics containing 1, 2, 4-oxadiazole, 1, 3, 4-oxadiazole, …

Receptors have well-conserved regions that are recognized and activated by hormones and
neurotransmitters. Most drugs bind to these sites and mimic or block the action of the native …

The effects of the selective 5-HT 1A receptor agonist (R)-8-hydroxy-2(di-n-propylamino)tetralin
[(R)-8-OH-DPAT] and the novel 5-HT 1A antagonist (S)-5-fluoro-8-hydroxy-2-(…