… Wrhler, professor of chemistry and pharmacology at the University of Grttingen, and Liebig,
professor of chemistry at the University of GieBen, had collaborated in this study. In addition …

… Schwanstecher C, Dickel C, Panten U: Cytosolic nucleotides … Schwanstecher C, Dickel C,
Panten U: Interaction of tolbutamide … Schwanstecher M, Panten U: Protein phosphorylation …

ATP-sensitive potassium channels (K ATP channels) are heteromultimers of sulfonylurea
receptors (SUR) and inwardly rectifying potassium channel subunits (K IR 6.x) with a (SUR–K …

As a thermal machining process, Electro-Discharge Machining (EDM) provides a means of
machining ceramic materials, irrespective of their hardness and strength, provided that their …

In the insulin secreting pancreatic B-cell, glucose is both fuel and physiological stimulus for
the initiation of insulin secretion and the regulation of insulin biosynthesis. This dual function …

The influence of the hypoglycemic drugs tolbutamide, meglitinide, glipizide and glibenclamide
on ATP-dependent K + currents of mouse pancreatic B-cells was studied using the whole-…

… Significances were calculated by the two-tailed Utest of Wilcoxon and of Mann and Whitney.
P < 0.05 was considered significant. Relations between drug concentrations and effects or …

LLeucine has been shown to s~ uIate insulin release in vivo [1, 2] and in vitro [3, 4]. It is
unknown whether Lleucine must be metabolized to elicit this effect. From in vivo experiments …

… Km value of 61 ± 14 µ / and a Vmax value of 2.6 ± 0.3 U/g protein for hexokinase (HK; lower
… were 2.20 ± 0.07 U/g protein (N = 3) for pancreatic islets and 1.95 ± 0.10 U/g protein (N = 3) …

The pancreatic beta-cell transduces the availability of nutrients into the secretion of insulin.
While this process is extensively modified by hormones and neurotransmitters, it is the …