For many decades, the design of new nucleoside analogs as potential therapeutic agents
focused on both sugar and nucleobase modifications. These nucleoside analogs rely on …

New discoveries in RNA biology underscore a need for chemical tools to clarify their roles in
pathophysiological mechanisms. In certain cancers, synthesis of the let-7 microRNA tumor …

In this study, we described the synthesis of 1,4- and 1,5-disubstituted-1,2,3-triazolo-nucleosides
from various alkynes with 1′-azido-2′,3′,5′-tri-O-acetylribose using either copper-…

… -TP and 2′-C-Me-GTP were chain terminators for genotype 1b HCV-pol, and single
nucleotide incorporation assays revealed that 2′-C-Me-DAPN-TP was incorporated opposite U. …

Acyclic nucleoside phosphonates (ANPs) are at the cornerstone of DNA virus and retrovirus
therapies. They reach their target, the viral DNA polymerase, after two phosphorylation steps …

β-D-3′-Azido-2′,3′-dideoxyguanosine (3′-azido-ddG) is a potent inhibitor of HIV-1
replication with a superior resistance profile to zidovudine. Recently, we identified five novel 6-…

… For cDNA synthesis 1 μl of reverse transcription mixture containing 2 u/μl AMV-RT (Roche,
diluted with PSB (9 mM Mg(OAc) 2 , 5 mM K 3 PO 4 pH 7.3, 95 mM potassium glutamate, 5 …

… were unable to separate the bisPOM-vinylphosphonate nucleosides from excess tetra(POM)-bisphosphonate
5 by flash silica gel column chromatography (except in the case of the U …

… D U 5 , U 6 , and U 7 binding to the interdomain linker and the RRM2-binding pocket. G 8
binding to the eRRM1 β-hairpin extension. E Cooperative binding by RRM1 and the U 6 and U …

Chemically synthesized single and multi-labeled oligonucleotides are enabling tools in
molecular diagnostics,[1–3] nanotechnologies,[4, 5] and other related fields. Most applications …