Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of
NO synthase (NOS; EC 1.14.13.39). They all utilize l-arginine and molecular oxygen as …

Nitric oxide (NO·) is an important protective molecule in the vasculature, and endothelial NO·
synthase (eNOS) is responsible for most of the vascular NO· produced. A functional eNOS …

Nitric oxide synthase (NOS) exists in three established isoforms. NOS I (NOS1, ncNOS) was
originally discovered in neurons. This enzyme and splice variants thereof have since been …

Incubation of endothelial cells in vitro with high concentrations of glucose activates protein
kinase C (PKC) and increases nitric oxide synthase (NOS III) gene expression as well as …

Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH (reduced
form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase, …

Angiotensin II infusion causes endothelial dysfunction by increasing NAD(P)H oxidase-mediated
vascular superoxide production. However, it remains to be elucidated how in vivo …

Nitric oxide (NO) is synthesized by at least three distinct isoforms of NO synthase (NOS).
Their substrate and cofactor requirements are very similar. All three isoforms have some …

Endothelium-derived nitric oxide (NO) is a paracrine factor that controls vascular tone, inhibits
platelet function, prevents adhesion of leukocytes, and reduces proliferation of the intima. …

Background— Estrogens can upregulate endothelial nitric oxide synthase (eNOS) in human
endothelial cells by increasing eNOS promoter activity and enhancing the binding activity of …

In the vascular wall, reactive oxygen species (ROS) are produced by several enzyme systems
including NADPH oxidase, xanthine oxidase, uncoupled endothelial nitric oxide synthase (…