[HTML][HTML] The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells

E Woldt, J Terrand, M Mlih, RL Matz, V Bruban… - Nature …, 2012 - nature.com
Vascular calcification is a hallmark of advanced atherosclerosis. Here we show that deletion
of the nuclear receptor PPARγ in vascular smooth muscle cells of low density lipoprotein …

Biological relevance of RGD‐integrin subtype‐specific ligands in cancer

…, D Reita, N Etienne‐Selloum, V Bruban… - …, 2021 - Wiley Online Library
Integrins are heterodimeric transmembrane proteins able to connect cells with the micro‐environment.
They represent a family of receptors involved in almost all the hallmarks of cancer. …

Synthesis and Biological Evaluation of Pyrrolinic Isosteres of Rilmenidine. Discovery of cis-/trans-Dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H- pyrrol-2-yl)-amine (LNP …

S Schann, V Bruban, K Pompermayer… - Journal of medicinal …, 2001 - ACS Publications
To find new compounds selective for purported I 1 imidazoline receptors (I 1 Rs) over I 2
imidazoline binding sites (I 2 BS) and α 2 -adrenoceptors (α 2 ARs), a series of pyrrolinic …

[HTML][HTML] Convergent signaling pathways controlled by LRP1 (receptor-related protein 1) cytoplasmic and extracellular domains limit cellular cholesterol accumulation

…, A Van Dorsselaer, J Herz, V Bruban… - Journal of Biological …, 2016 - ASBMB
The low density lipoprotein receptor-related protein 1 (LRP1) is a ubiquitously expressed
cell surface receptor that protects from intracellular cholesterol accumulation. However, the …

Respective contributions of α‐adrenergic and non‐adrenergic mechanisms in the hypotensive effect of imidazoline‐like drugs

V Bruban, J Feldman, H Greney… - British journal of …, 2001 - Wiley Online Library
The hypotensive effect of imidazoline‐like drugs, such as clonidine, was first attributed to the
exclusive stimulation of central α 2 ‐adrenoceptors (α 2 ARs). However, a body of evidence …

[HTML][HTML] Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptor

…, C Gracia, S Foppolo, S Martin, V Bruban… - Journal of Biological …, 2011 - ASBMB
The low density lipoprotein receptor-related protein (LRP1) is a transmembrane receptor that
integrates multiple signaling pathways. Its cytoplasmic domain serves as docking sites for …

Evidence for Synergy Between α2-Adrenergic and Nonadrenergic Mechanisms in Central Blood Pressure Regulation

V Bruban, V Estato, S Schann, JD Ehrhardt… - Circulation, 2002 - Am Heart Assoc
Background— Both α 2 -adrenergic and non–α 2 -adrenergic mechanisms seem to be involved
in the hypotensive effect of imidazoline-like drugs. This study aimed at investigating how …

[HTML][HTML] Cav1/EREG/YAP axis in the treatment resistance of Cav1-expressing head and neck squamous cell carcinoma

M Burgy, A Jehl, O Conrad, S Foppolo, V Bruban… - Cancers, 2021 - mdpi.com
Simple Summary The EGFR-targeting antibody cetuximab (CTX) combined with radiotherapy
has been proven effective for the treatment of locally advanced head and neck squamous …

[125I] 2-(2-Chloro-4-iodo-phenylamino)-5-methyl-pyrroline (LNP 911), a High-Affinity Radioligand Selective for I1Imidazoline Receptors

…, D Urosevic, S Schann, L Dupuy, V Bruban… - Molecular …, 2002 - ASPET
The I 1 subtype of imidazoline receptors (I 1 R) is a plasma membrane protein that is involved
in diverse physiological functions. Available radioligands used so far to characterize the I 1 …

Imidazoline receptors: a challenge

P Bousquet, V Bruban, S Schann, J Feldman - Pharmacochemistry Library, 2000 - Elsevier
The hypotensive effect of imidazoline-like drugs (IMs) directly injected into the rostroventrolateral
part of the brainstem (NRL/RVLM) was shown to involve non-adrenergic imidazoline …