Acetylcholinesterase: Specific inactivation of allosteric effects by a water-soluble carbodiimide

BD Roufogalis, VM Wickson - Journal of Biological Chemistry, 1973 - Elsevier
Activation of acetylcholinesterase by divalent cations and some quaternary ammonium
compounds is believed to be mediated through allosteric anionic sites. Treatment with N-…

[PDF][PDF] Acetylcholinesterase: Specificity of the peripheral anionic site for cholinergic ligands

BD Roufogalis, VM Wickson - Molecular Pharmacology, 1975 - Citeseer
ROUFOGALIS, BASIL D. & WICKSON, VIRGINIA M.(1975) Acetylcholinesterase: Specificity
of the peripheral anionic site for cholinergic ligands. Mol. Pharmacol., 11, 352-360 The …

Effect of ligands on a discontinuous temperature dependence of the decarbamylation reaction of erythrocyte acetylcholinesterase

BD Roufogalis, EE Quist, VM Wickson - Biochim Biophys Acta, 1973 - apps.dtic.mil
The report describes the effect of temperature on the decarbamylation of dimethylcarbamylated
acetylcholinesterase, and on the activation of this reaction by ligands. Discontinuities in …

The stability of β-galactosidase in the presence of urea

VM Wickson, RE Huber - Biochimica et Biophysica Acta (BBA)-Protein …, 1969 - Elsevier
The loss of activity of β-galactosidase (EC 3.2.1.23) in urea was studied in relation to changes
in urea concentration, buffer, temperature, pH, solvent, ionic strength, substrate, inhibitors, …

The non-simultaneous dissociation and loss of activity of β-galactosidase in urea

VM Wickson, RE Huber - Biochimica et Biophysica Acta (BBA)-Protein …, 1970 - Elsevier
In the presence of urea the loss of activity and the dissociation of β-galactosidase (EC 3.2.1.23)
into subunits were not parallel reactions. The activity loss was more rapid than the loss of …

[PDF][PDF] Influence of temperature and cholinergic ligands on the carbamylation of unmodified and carbodiimide-modified erythrocyte acetylcholinesterase

BD Roufogalis, VM Wickson - FEBS letters, 1974 - core.ac.uk
A number of previous studies have shown that the hydrolysis of acetylcholine by
acetylcholinesterase (EC 3.1. 1.7) from a number of sources is accelerated by selected ligands [l-3]. It …

[HTML][HTML] Valuing nature's contributions to people: the IPBES approach

…, M Van den Belt, M Verma, F Wickson… - Current opinion in …, 2017 - Elsevier
Highlights • Nature and its contributions to people’s quality of life are associated with a wide
diversity of values. • IPBES embraces this diversity of values, as well as the need to integrate …

Exploiting the potential of large databases of electronic health records for research using rapid search algorithms and an intuitive query interface

…, N Beloff, B Al-Radwan, J Wickson… - Journal of the …, 2014 - academic.oup.com
Objective UK primary care databases, which contain diagnostic, demographic and prescribing
information for millions of patients geographically representative of the UK, represent a …

High-resolution carbon isotope stratigraphy of the Ordovician-Silurian boundary on Anticosti Island, Quebec: Regional and global implications

S Wickson - 2011 - ruor.uottawa.ca
The end-Ordovician was a critical time in Earth history and marked the occurrence of a mass
extinction and a period of continental glaciation. The Ellis Bay Formation on Anticosti Island …

[HTML][HTML] Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure

…, A Park, Y Ikeda, X Li, LM Mayr, K Wickson… - Nature …, 2022 - nature.com
The dysregulated physical interaction between two intracellular membrane proteins, the
sarco/endoplasmic reticulum Ca 2+ ATPase and its reversible inhibitor phospholamban, …