Several lines of evidence have suggested that iron is critical for Mycobacterium tuberculosis
growth in macrophages.Macrophage iron loading in patients with African iron overload …

Pulmonary hypertension affects ∼10% of adult patients with sickle cell disease (SCD),
particularly those with the homozygous genotype. An increase in pulmonary artery systolic …

Sickle cell disease (SCD), caused by a mutation in the β-globin gene HBB, is widely
distributed in malaria endemic regions. Cardiopulmonary complications are major causes of …

Background Iron overload and hemochromatosis are common, treatable conditions. HFE
genotypes, levels of serum ferritin, transferrin saturation values, and self-reported medical …

Background The up-regulation of P-selectin in endothelial cells and platelets contributes to
the cell–cell interactions that are involved in the pathogenesis of vaso-occlusion and sickle …

Chuvash polycythemia is an autosomal recessive disorder that is endemic to the mid-Volga
River region. We previously mapped the locus associated with Chuvash polycythemia to …

Background Deoxygenated sickle hemoglobin (HbS) polymerization drives the pathophysiology
of sickle cell disease. Therefore, direct inhibition of HbS polymerization has potential to …

Background Oxidative stress contributes to the complex pathophysiology of sickle cell disease.
Oral therapy with pharmaceutical-grade l-glutamine (USAN, glutamine) has been shown …

Tibetans do not exhibit increased hemoglobin concentration at high altitude. We describe a
high-frequency missense mutation in the EGLN1 gene, which encodes prolyl hydroxylase 2 (…

Background. The mechanisms by which testosterone increases hemoglobin and hematocrit
remain unclear. Methods. We assessed the hormonal and hematologic responses to …